C5orf47 Inhibitors
C5orf47 inhibitors encompass a range of compounds that target various signaling pathways and cellular processes to decrease the functional activity of the protein. Alkaloid compounds that inhibit protein kinases play a crucial role by suppressing kinase-mediated phosphorylation events, a process that C5orf47 is involved in, thereby reducing its activity. Inhibition of the PI3K/AKT pathway by specific compounds disrupts crucial downstream effects, leading to a reduction in C5orf47 activation. The use of mTOR inhibitors further exemplifies the strategic blockade of cell growth and proliferation pathways, which are essential for the regulation of proteins like C5orf47. The intervention at the level of MEK inhibits the MAPK pathway, decreasing regulatory effects on cell proliferation and differentiation where C5orf47 may be implicated. Similarly, interfering with NUAK kinases can perturb cellular energy homeostasis, potentially decreasing C5orf47 function if it plays a role in metabolic regulation.
Further targeting includes the inhibition of AKT phosphorylation, which disrupts AKT signaling and subsequently affects downstream proteins such as C5orf47. MEK5/ERK5 pathway inhibitors also contribute to the decreased activity of C5orf47 by altering signaling involved in core cellular functions. Compounds that inhibit JNK dampen the signaling involved in apoptosis and cellular stress responses, which can indirectly reduce C5orf47 activity. Selective inhibition of p38 MAPK affects the associated signaling pathways, potentially leading to decreased C5orf47 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
This alkaloid compound inhibits protein kinases, leading to the suppression of kinase-mediated phosphorylation events that C5orf47 may be involved in, thereby reducing its functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, it disrupts the PI3K/AKT signaling pathway. C5orf47, implicated in cellular processes regulated by this pathway, would experience decreased activation due to this interference. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, it diminishes the activity of the mTOR signaling pathway which is crucial for cell growth and proliferation. C5orf47, if participating in these cellular functions, would have reduced activity as a result. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
This compound is an inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. Inhibition of this pathway can lead to decreased regulation of proteins such as C5orf47 that are involved in cell proliferation and differentiation processes. | ||||||
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
By inhibiting NUAK kinases, this compound interferes with cellular energy homeostasis and could decrease the functional activity of C5orf47 if it is involved in metabolic regulation. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
This compound specifically inhibits AKT phosphorylation, disrupting the AKT signaling pathway. This can lead to reduced activity of downstream proteins like C5orf47 that are regulated by AKT signaling. | ||||||
BIX 02189 | 1094614-85-3 | sc-364436 sc-364436A | 5 mg 10 mg | $220.00 $378.00 | 5 | |
An inhibitor of the MEK5/ERK5 pathway, it interferes with signaling involved in cell proliferation and differentiation, potentially diminishing C5orf47 activity if it is associated with this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
This compound inhibits JNK, affecting the JNK signaling pathway involved in apoptosis and cellular stress responses. If C5orf47 functions within this pathway, its activity would be indirectly inhibited. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A selective inhibitor of p38 MAPK, it disrupts the p38 signaling pathway, which could lead to decreased activation of C5orf47 if it is implicated in inflammatory responses or stress-related cellular processes. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
An EGFR tyrosine kinase inhibitor, it impedes the EGFR signaling pathway. C5orf47, if it interacts with components of this pathway, would have its activity reduced as a consequence of pathway inhibition. | ||||||