C2orf68_0610030E20Rik Inhibitors
Inhibitors like staurosporine and U0126 function by hindering the activity of kinases, which are crucial for the phosphorylation and activation of many proteins involved in signaling pathways. Compounds such as LY294002 and wortmannin target specific kinases within the PI3K/AKT/mTOR pathway, a central conduit for signals that regulate cell growth, proliferation, and survival. These inhibitors can modulate the activity of proteins that are regulated by phosphorylation and dephosphorylation events.
Likewise, rapamycin and its analogs inhibit the mTOR pathway, which is deeply integrated with protein synthesis and autophagy, affecting a wide array of cellular functions. Brefeldin A and cycloheximide, on the other hand, disrupt fundamental cellular processes such as protein transport and synthesis, respectively, thus impacting protein function on a broad scale. Compounds such as 2-Deoxy-D-glucose interfere with energy production pathways like glycolysis, which could impact proteins that require ATP for their activity. MG132 inhibits the ubiquitin-proteasome system, leading to the accumulation of proteins that are usually targeted for degradation, potentially affecting protein turnover and function.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent, non-selective inhibitor of protein kinases that can modulate signal transduction pathways and affect protein activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A specific inhibitor of PI3K, which is involved in the AKT signaling pathway. It can affect proteins regulated by this pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, which can alter downstream protein synthesis and cellular proliferation, potentially affecting proteins regulated by mTOR. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
A specific inhibitor of p38 MAP kinase, affecting inflammation and stress response pathways, thereby influencing protein activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A selective inhibitor of MEK, which blocks the MAPK/ERK pathway, potentially affecting proteins that are dependent on this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A phosphoinositide 3-kinase inhibitor that can impact various signaling pathways, including those that regulate protein function and cell growth. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
An inhibitor of ADP-ribosylation factor, which disrupts protein transport within cells, potentially affecting protein localization and function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
An inhibitor of eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, thus affecting protein expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glycolysis inhibitor that can reduce ATP production, thereby influencing proteins that are dependent on cellular energy levels. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor, which can prevent protein degradation and potentially alter the levels and activity of various proteins. | ||||||