C22orf25 Activators

Transport and Golgi organization 2 homolog (TANGO2) is a protein that plays a significant role in the cellular processes related to the transport of cargo within the endoplasmic reticulum (ER) and the Golgi apparatus. The TANGO2 gene encodes the protein, which is implicated in the mechanisms governing the homeostasis and organization of these essential organelles in the secretory pathway.TANGO2 is involved in the intricate process of exporting bulky cargoes, such as large proteins or protein complexes, from the ER. It facilitates the collection and packaging of these cargoes into transport vesicles, which are then shuttled to the Golgi apparatus for further processing, modification, and sorting. The protein works in conjunction with other molecules involved in the shaping of the membrane and the selection of cargo, ensuring that proteins reach their correct destinations within the cell or are secreted out of the cell.

The functional significance of TANGO2 extends beyond transport, as it is also involved in maintaining the structural integrity and organization of the Golgi stacks. This is crucial for the proper processing and maturation of proteins, as the Golgi apparatus is the central hub where post-translational modifications like glycosylation occur.Mutations in the TANGO2 gene can lead to a spectrum of cellular dysfunctions, highlighting the protein's importance. These mutations have been associated with a rare genetic condition known as TANGO2-related metabolic encephalopathy and arrhythmias.