C19orf39 Inhibitors
C19orf39 inhibitors are a class of compounds that act on various signaling pathways and cellular processes to indirectly inhibit the activity of C19orf39. These inhibitors include kinase inhibitors such as Staurosporine, which through its broad-spectrum kinase inhibition, may disrupt phosphorylation-dependent functions of C19orf39. U0126 inhibits MEK1/2, consequently reducing ERK1/2 signaling, which could diminish C19orf39 activity if it relies on this pathway. LY294002 and Rapamycin target the PI3K/AKT/mTOR pathway; the former by inhibiting PI3K and the latter by inhibiting mTOR, both of which could decrease C19orf39 activity by interfering with the survival and proliferation signals.
ATR inhibitor VE-821 and ATM inhibitor KU-55933 specifically target the ATR and ATM kinases, respectively, which are critical for DNA damage response. Inhibition of these kinases could lead to a reduced DNA damage response where C19orf39 is potentially involved, thereby inhibiting its function. The proteasome inhibitor Bortezomib could lead to the accumulation of misfolded or damaged proteins, affecting C19orf39 if it is subject to proteasomal degradation. Hsp90 inhibitor 17-AAG could destabilize C19orf39 if it is an Hsp90 client protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a non-selective protein kinase inhibitor that disrupts multiple cell signaling pathways, including those that control cell cycle progression and apoptosis. It can inhibit DNA repair-associated kinases that might be necessary for C19orf39 function, thus inhibiting C19orf39 by preventing essential phosphorylation events. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, by antagonizing adenosine receptors, can indirectly lead to the inhibition of the cell cycle checkpoint kinases, potentially reducing C19orf39 activity if it is involved in cell cycle regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, leading to reduced ERK1/2 signaling. If C19orf39 requires ERK1/2 activity to function, such as for DNA damage response, its activity would be compromised by U0126. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, leading to reduced AKT signaling and subsequent downstream effects. If C19orf39 is dependent on PI3K/AKT for its function, this compound would diminish its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth. If C19orf39 is involved in mTOR signaling, its inhibition by rapamycin could lead to decreased C19orf39 activity. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 inhibits Chk1 and Chk2, preventing cell cycle arrest and DNA repair. If C19orf39 functions within these pathways, its activity would be inhibited by AZD7762. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 stabilizes p53, leading to cell cycle arrest. If C19orf39 is involved in pathways regulated by p53, Nutlin-3 could indirectly inhibit C19orf39. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib inhibits PARP, a key enzyme in single-strand DNA break repair. If C19orf39 is involved in DNA repair pathways, inhibition by Olaparib would reduce its activity. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 inhibits ATM kinase, a key regulator of the DNA damage response. If C19orf39 functions downstream of ATM, its activity would be inhibited by KU-55933. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 inhibits ATR kinase, disrupting DNA damage response and repair. If C19orf39 is part of the ATR-signaling pathway, it would be inhibited by VE-821. | ||||||