C18orf34 Inhibitors

Coiled-coil domain-containing 178 (CCDC178) is a protein that, as implied by its name, features a coiled-coil domain, which is a structural motif characterized by the intertwining of two or more alpha-helices into a supercoil structure. This motif is commonly involved in facilitating protein-protein interactions, suggesting that CCDC178 may play a role in a variety of cellular processes through its ability to form complexes with other proteins.The precise biological function of CCDC178 is not fully characterized, but proteins with coiled-coil domains are often implicated in various aspects of cell biology, including vesicle trafficking, cytoskeletal organization, and the regulation of gene expression. CCDC178, by virtue of its domain structure, may similarly be engaged in one or multiple such cellular activities.

The coiled-coil domain typically facilitates the oligomerization of proteins and is involved in the assembly of multiprotein complexes. Therefore, CCDC178 may participate in the formation of structures necessary for maintaining cell shape, intracellular transport, and cell signaling. The protein could be a component of the cytoskeleton or involved in the dynamics of cytoskeleton-associated processes, such as mitosis or cell motility.Given the general role of coiled-coil domain-containing proteins, CCDC178 might also be involved in intracellular trafficking pathways, such as the transport of vesicles between organelles like the Golgi apparatus and the plasma membrane. This process is critical for the secretion of proteins and lipids and for the retrieval of membrane components.Mutations or alterations in the expression of genes encoding coiled-coil domain proteins can have significant effects on cellular function and have been associated with various diseases. As such, understanding the specific interactions and functions of CCDC178 could have implications for the study of diseases where protein aggregation, trafficking, and cellular architecture are disrupted.