C15orf41 Activators
C15orf41 is ostensibly linked to DNA repair processes. The identified chemicals mainly exert their influence by either directly damaging DNA or by inhibiting certain components of the DNA repair machinery. Such interventions necessitate a cellular response to maintain genome integrity. For example, Hydroxyurea increases DNA damage, which can escalate DNA repair pathways, whereas Olaparib, impairs base excision repair, possibly causing a compensatory rise in other repair pathways. On similar lines, Cisplatin and Camptothecin introduce DNA crosslinks and inhibit DNA topoisomerase I, respectively, both leading to DNA damage and a upsurge in repair activities.
Another group of chemicals, including VE-821 and KU-55933, directly target pivotal kinases in DNA repair pathways. These chemicals can usher alterations in the DNA repair landscape. Similarly, NU7441 targets DNA topoisomerases and non-homologous end joining, respectively. Alkylating agents, like MMS, and nucleoside analogs, such as 5-Azacytidine and 6-Thioguanine, further exemplify the category of DNA damaging agents that might indirectly evoke a response involving C15orf41. Collectively, these chemicals, by shaping the DNA damage and repair milieu, can influence the activity or expression of C15orf41.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea can increase DNA damage, which can indirectly upregulate DNA repair pathways, possibly leading to increased activity or expression of C15orf41. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
As a PARP inhibitor, Olaparib compromises base excision repair, which can cause a compensatory increase in other repair pathways, possibly influencing C15orf41. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin induces DNA crosslinks. Increased DNA damage might indirectly elevate DNA repair activities, possibly affecting C15orf41 function or expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, leading to DNA damage and an upregulation of repair pathways, which can indirectly influence C15orf41. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
By inhibiting ATR, VE-821 affects the response to replication stress and DNA damage, possibly leading to modulation of DNA repair proteins including C15orf41. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 inhibits ATM, a crucial kinase in DNA double-strand break repair, potentially causing alterations in repair pathways that might impact C15orf41. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide targets DNA topoisomerase II, causing DNA damage. This can lead to increased DNA repair activity, which might affect C15orf41. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
By inhibiting DNA-PK, NU7441 impacts non-homologous end joining, a DNA repair mechanism, which might indirectly modulate the function or expression of C15orf41. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
MMS is an alkylating agent causing DNA damage, possibly leading to upregulation of DNA repair pathways and impacting proteins like C15orf41. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin inhibits DNA polymerases and can cause replication stress. This can indirectly stimulate DNA repair processes that involve C15orf41. | ||||||