C15orf41 Activators

C15orf41 is ostensibly linked to DNA repair processes. The identified chemicals mainly exert their influence by either directly damaging DNA or by inhibiting certain components of the DNA repair machinery. Such interventions necessitate a cellular response to maintain genome integrity. For example, Hydroxyurea increases DNA damage, which can escalate DNA repair pathways, whereas Olaparib, impairs base excision repair, possibly causing a compensatory rise in other repair pathways. On similar lines, Cisplatin and Camptothecin introduce DNA crosslinks and inhibit DNA topoisomerase I, respectively, both leading to DNA damage and a upsurge in repair activities.

Another group of chemicals, including VE-821 and KU-55933, directly target pivotal kinases in DNA repair pathways. These chemicals can usher alterations in the DNA repair landscape. Similarly, NU7441 targets DNA topoisomerases and non-homologous end joining, respectively. Alkylating agents, like MMS, and nucleoside analogs, such as 5-Azacytidine and 6-Thioguanine, further exemplify the category of DNA damaging agents that might indirectly evoke a response involving C15orf41. Collectively, these chemicals, by shaping the DNA damage and repair milieu, can influence the activity or expression of C15orf41.