Date published: 2025-12-18

1-800-457-3801

SCBT Portrait Logo
Seach Input

C10orf30 Activators

C10orf30 Activators encompass a variety of chemical compounds that indirectly stimulate the functional activity of C10orf30 through diverse signaling pathways. Compounds such as Forskolin, IBMX, Rolipram, and 8-Br-cAMP operate through mechanisms that elevate intracellular levels of cAMP, a crucial secondary messenger, which in turn activates protein kinase A (PKA). PKA is known for its ability to phosphorylate a myriad of proteins, potentially including C10orf30, thereby enhancing its activity. Similarly, PMA acts through the activation of Protein Kinase C (PKC), which may phosphorylate C10orf30 or influence other kinases that modulate C10orf30 activity. Calcium signaling also plays a significant role, with compounds like Ionomycin, A23187, and Thapsigargin increasing intracellular calcium levels. This elevation can activate calcium/calmodulin-dependent kinases and other calcium-sensitive signaling molecules, which might then lead to the activation of C10orf30.

The modulation of various kinase pathways is an additional strategy by which C10orf30 activity can be enhanced. LY294002 and U0126 exert their effects by inhibiting PI3K and MEK1/2, respectively, creating a shift in signaling pathways that could favor the activation of C10orf30. Meanwhile, SP600125 and SB203580 target the JNK and p38 MAPK pathways, inhibiting these kinases, which could relieve negative regulatory influences on C10orf30 or engage compensatory pathways that enhance C10orf30's activity. Through these diverse mechanisms, these activators indirectly enhance the functional activity of C10orf30 by altering the phosphorylation state, second messenger levels, and kinase signaling dynamics within cells, without upregulating the expression or requiring direct activation of C10.

SEE ALSO...

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

IBMX

28822-58-4sc-201188
sc-201188B
sc-201188A
200 mg
500 mg
1 g
$159.00
$315.00
$598.00
34
(1)

IBMX inhibits phosphodiesterases, preventing cAMP degradation. Persistently high cAMP levels can indirectly lead to increased activity of C10orf30 via PKA activation.

Rolipram

61413-54-5sc-3563
sc-3563A
5 mg
50 mg
$75.00
$212.00
18
(1)

Rolipram inhibits PDE4, leading to increased cAMP levels and PKA activation. PKA could then enhance C10orf30 activity through phosphorylation.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates Protein Kinase C (PKC), which may lead to downstream phosphorylation events that could enhance the functional activity of C10orf30.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$76.00
$265.00
80
(4)

Ionomycin increases intracellular calcium levels, potentially modulating calcium-calmodulin dependent kinases which could indirectly enhance C10orf30 activity.

A23187

52665-69-7sc-3591
sc-3591B
sc-3591A
sc-3591C
1 mg
5 mg
10 mg
25 mg
$54.00
$128.00
$199.00
$311.00
23
(1)

A23187 acts as a calcium ionophore, raising intracellular calcium levels and possibly activating calcium-dependent signaling pathways that may enhance C10orf30.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), elevating cytosolic calcium levels, which could indirectly activate C10orf30 through calcium-mediated signaling.

8-Bromoadenosine 3′,5′-cyclic monophosphate

23583-48-4sc-217493B
sc-217493
sc-217493A
sc-217493C
sc-217493D
25 mg
50 mg
100 mg
250 mg
500 mg
$106.00
$166.00
$289.00
$550.00
$819.00
2
(1)

8-Br-cAMP is a cAMP analog that activates PKA. PKA-mediated phosphorylation could enhance C10orf30 activity.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor that may shift the balance of cellular signaling pathways, indirectly enhancing C10orf30 activity through alternative pathways.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 inhibits MEK1/2, potentially influencing downstream pathways that could indirectly activate C10orf30 by reducing negative regulatory influences.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 inhibits JNK, which may lead to adjustments in cellular signaling pathways that could indirectly enhance the activity of C10orf30.