BTR1 Activators
BTR1 activators are a diverse group of molecules that primarily exert their biological effects through the modulation of cyclic AMP (cAMP) levels within cells. The common functional mechanism across these compounds involves either the direct activation of adenylate cyclase, such as forskolin, resulting in increased cAMP synthesis, or the inhibition of cAMP-degrading phosphodiesterases (PDEs), exemplified by IBMX, rolipram, theophylline, and various other PDE inhibitors.
By increasing intracellular cAMP levels, these compounds indirectly activate protein kinase A (PKA), which can then phosphorylate a wide range of substrates. This phosphorylation cascade represents a classic intracellular signaling pathway, with PKA acting as a pivotal mediator that translates the increase in cAMP into specific cellular responses, including changes in protein function, gene expression, and metabolic regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of PKA and subsequent phosphorylation of target proteins, potentially including BTR1 if it is a PKA substrate. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which degrades cAMP. By preventing cAMP degradation, IBMX indirectly increases PKA activity, which may activate BTR1 if it is regulated by PKA. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels in certain cell types, potentially inducing PKA activation and influencing BTR1 activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G-protein-coupled receptors, potentially elevating intracellular cAMP and activating PKA, which may affect BTR1 if it is cAMP-responsive. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic analog of adrenaline that activates beta-adrenergic receptors, increasing intracellular cAMP and activating PKA, possibly affecting BTR1 activity. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline is a non-selective phosphodiesterase inhibitor that elevates cAMP levels, enhancing PKA activity and potentially influencing BTR1 activity. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $150.00 | ||
Anagrelide inhibits PDE3, which increases cAMP levels and activates PKA, possibly affecting BTR1 if cAMP/PKA signaling regulates its activity. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is a flavonoid that can inhibit PDEs, increasing cAMP and activating PKA, which may modulate BTR1 activity if BTR1 is influenced by this pathway. | ||||||