Brg-1 Inhibitors
Brg-1 inhibitors belong to a specific class of compounds designed to modulate the activity of Brahma-Related Gene 1 (Brg-1), a protein that serves as a catalytic subunit of the SWI/SNF chromatin remodeling complex. These inhibitors are meticulously developed to interact with Brg-1, affecting its enzymatic function in chromatin remodeling and gene transcription regulation. The SWI/SNF complex, with Brg-1 as a key component, plays a crucial role in altering the structure of chromatin to facilitate gene expression and cellular responses to various stimuli. By selectively engaging with Brg-1, these inhibitors can impact processes such as gene regulation, DNA repair, and cell differentiation. Brg-1 inhibitors can encompass a range of chemical structures, including small molecules or peptides, designed to effectively target Brg-1's functional domains.
The primary purpose of developing Brg-1 inhibitors is to investigate the intricate mechanisms by which the SWI/SNF complex, and particularly Brg-1, modulates chromatin structure and gene expression. By modulating Brg-1 activity, researchers can gain insights into how this protein orchestrates chromatin remodeling events, influencing transcriptional responses and cellular behaviors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PFI 3 | 1819363-80-8 | sc-507340 | 10 mg | $300.00 | ||
PFI-3 is a synthetic inhibitor that specifically targets the bromodomain of BRGIt competes with the binding of acetylated histones to the BRG1 bromodomain, interfering with BRG1's chromatin remodeling activity. | ||||||
PF-3758309 | 898044-15-0 | sc-478493 | 10 mg | $260.00 | ||
This is another synthetic small-molecule inhibitor that targets BRGIt has been studied for its potential anti-cancer effects by inhibiting BRG1-mediated oncogenic transcription. | ||||||
BI 9564 | 1883429-22-8 | sc-507350 | 1 mg | $83.00 | ||
This is a potent and selective chemical probe for BRD9 and BRDIt has been used in research to study the roles of these bromodomain proteins, including their relationship with BRG1. | ||||||
RVX 208 | 1044870-39-4 | sc-472700 | 10 mg | $340.00 | ||
While primarily known as an inhibitor of bromodomain-containing protein 4 (BRD4), RVX-208 has also been found to inhibit BRG1 activity, affecting gene expression and chromatin remodeling. | ||||||
2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one | 955365-80-7 | sc-483196 | 5 mg | $340.00 | 1 | |
AZD-1775 is a selective inhibitor of WEE1 kinase, but it has also been reported to affect BRG1 expression and function in certain contexts. | ||||||