Brg-1 Activators
Common Brg-1 Activators include, but are not limited to Rotenone CAS 83-79-4, Manganese(II) chloride beads CAS 7773-01-5, Paraquat chloride CAS 1910-42-5, Copper(II) sulfate CAS 7758-98-7 and Iron(III) chloride CAS 7705-08-0.
Brg-1 activators represent a chemical class known for their ability to modulate the activity of Brahma-related gene 1 (Brg-1), a critical component of the SWI/SNF chromatin remodeling complex. This complex plays a pivotal role in regulating gene expression by altering the accessibility of DNA to the transcriptional machinery. Brg-1, as an ATPase subunit of SWI/SNF, is involved in chromatin restructuring, impacting a broad array of cellular processes, including cell differentiation, proliferation, and DNA repair. Brg-1 activators are experimental compounds that have garnered attention in the realm of basic research, as they provide a means to investigate the intricate mechanisms through which chromatin remodeling contributes to gene regulation.
Members of the Brg-1 activator class encompass a range of molecules, such as small organic compounds and experimental agents, which have demonstrated the ability to enhance Brg-1 activity. These compounds are invaluable tools for understanding the intricacies of chromatin remodeling processes. By influencing Brg-1 function, researchers can unravel the influence of this complex on gene expression in various cellular contexts. This class serves as a foundation for fundamental studies, shedding light on the epigenetic control of genes, which is crucial for diverse biological processes, but it's important to emphasize that these activators are primarily employed for exploratory research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone, a mitochondrial complex I inhibitor, may induce oxidative stress leading to an increase in α-synuclein expression as a cellular response. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese exposure is associated with increased α-synuclein expression, potentially due to alterations in neuronal oxidative stress and mitochondrial dysfunction. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $149.00 | 7 | |
Paraquat, a herbicide, might increase α-synuclein expression by inducing oxidative stress and mitochondrial impairment in neuronal cells. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper ions may induce α-synuclein expression by interacting with neuronal cells and influencing oxidative stress pathways. | ||||||
Iron | 7439-89-6 | sc-215190 sc-215190A | 500 g 2 kg | $68.00 $176.00 | ||
Iron ions are implicated in the upregulation of α-synuclein, potentially via influencing iron homeostasis and oxidative stress in neurons. | ||||||
Aluminum chloride anhydrous | 7446-70-0 | sc-214528 sc-214528B sc-214528A | 250 g 500 g 1 kg | $92.00 $97.00 $133.00 | ||
Aluminum exposure may enhance α-synuclein expression, likely through neurotoxic effects that include oxidative stress and mitochondrial dysfunction. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $83.00 | ||
Lead exposure is linked to elevated α-synuclein expression, potentially via mechanisms involving oxidative stress and neuronal injury. | ||||||