BMP2K Activators
BMP2K Activators are a diverse array of chemical compounds that enhance the functional activity of BMP2K through a variety of signaling mechanisms. Forskolin, for instance, raises intracellular cAMP levels, which subsequently activates protein kinase A (PKA). PKA can then phosphorylate and enhance the activity of BMP2K. Lithium Chloride operates through the inhibition of GSK-3β, releasing the suppression on Wnt/β-catenin signaling, a pathway known to interact with BMP2K signaling. SB431542's inhibition of ALK5, a TGF-β type I receptor, lessens competitive TGF-β signaling, which can result in an upregulation of BMP2K activity. Trichostatin A and 5-Azacytidine, through epigenetic alterations, promote a more permissive chromatin state, which could increase the transcriptional activation of components upstream of BMP2K, thereby enhancing its activity.
Additional BMP2K Activators include PD98059, which, by inhibiting MEK, may prevent MAPK pathway-mediated negative feedback effects on BMP2K, while LY294002's inhibition of PI3K could alter downstream signaling to favor BMP2KBMP2K Activators comprise a curated set of chemical compounds that indirectly but specifically enhance the activity of BMP2K within its signaling pathways. Forskolin, by increasing intracellular cAMP levels, indirectly activates BMP2K through the phosphorylation cascade mediated by PKA, which can phosphorylate substrates that enhance BMP2K's functional role. Lithium Chloride mediates its effect by inhibiting GSK-3β, lifting repression on Wnt/β-catenin pathway components that may interact with BMP2K signaling, leading to its activation. SB431542, by inhibiting the TGF-β type I receptor ALK5, potentially augments BMP2K activity by alleviating competitive inhibition from TGF-β signaling. Trichostatin A, as a histone deacetylase inhibitor, may promote a transcriptionally favorable chromatin environment, leading to the upregulation of genes that activate BMP2K. Similarly, 5-Azacytidine can activate genes in the BMP2K signaling cascade by reducing DNA methylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate BMP2K, enhancing its kinase activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, a negative regulator of the Wnt/β-catenin pathway. Inhibition of GSK-3β can lead to the stabilization of factors that increase BMP2K activity in the pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-β type I receptor ALK5, which when inhibited can enhance BMP signaling by reducing competitive signaling, leading to increased BMP2K activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is a histone deacetylase inhibitor, which can lead to a more relaxed chromatin structure and indirectly increase the access of transcription factors that enhance BMP2K expression and activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can lead to demethylation and activation of genes involved in the BMP2K signaling cascade. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor which can prevent negative feedback loops within the MAPK pathway, potentially increasing the activity of BMP2K by reducing its phosphorylation and inactivation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modulate the PI3K/Akt pathway, leading to altered cellular responses that could enhance the activity of BMP2K indirectly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that may enhance BMP signaling pathways by reducing actin cytoskeletal tension, which could indirectly increase BMP2K's functional activity. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
Dorsomorphin is an inhibitor of BMP type I receptors ALK2, ALK3, and ALK6. By selectively inhibiting these receptors, it can modulate their signaling and indirectly enhance BMP2K activity. | ||||||
Puerarin | 3681-99-0 | sc-202301 sc-202301A | 5 mg 100 mg | $129.00 $205.00 | 1 | |
Puerarin, an isoflavone, can influence BMP signaling by modulating estrogen receptor pathways, which indirectly can lead to the activation of BMP2K. | ||||||