Bmi-1 Activators
Common Bmi-1 Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Cobalt(II) chloride CAS 7646-79-9, β-Estradiol CAS 50-28-2 and Hydrogen Peroxide CAS 7722-84-1.
BMI-1 (B lymphoma Mo-MLV insertion region 1) is a member of the polycomb group (PcG) family of proteins. It plays a crucial role in regulating the proliferative activity of stem cells and is implicated in various human malignancies due to its role in cellular senescence and DNA damage response. Bmi-1 Activators are a class of compounds that influence the activity of the BMI1 (B-cell-specific Moloney murine leukemia virus integration site 1) protein. BMI1 is a crucial component of the Polycomb Repressive Complex 1 (PRC1), which is involved in the epigenetic regulation of gene expression. Specifically, BMI1 is known for its role in maintaining the self-renewal and proliferative capacity of stem cells, including hematopoietic, neural, and epithelial stem cells. It achieves this by suppressing the expression of genes associated with cell cycle arrest and senescence. Activation of BMI1 can lead to a reduction in these repressive gene expressions, thereby promoting the self-renewal and regeneration of stem cells.
The regulation of BMI1 is complex and multifaceted. Bmi-1 Activators, whether endogenous or exogenous, are substances or signaling pathways that impact BMI1's activity positively. These activators can facilitate the transcription of BMI1 or modulate its interactions with other proteins in the PRC1 complex. This class of compounds plays a pivotal role in the field of stem cell biology and regenerative medicine, as they offer a means to control and harness the regeneration of stem cells for various applications. Research in this area seeks to elucidate the precise mechanisms by which BMI1 is activated and its downstream effects on stem cell behavior, with the ultimate goal of manipulating stem cells for tissue repair. Understanding the role of Bmi-1 Activators in stem cell biology is a significant stride toward stem cell function in a wide range of medical conditions and injuries.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Known to modulate differentiation and could affect BMI-1 expression. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Can induce inflammatory responses, potentially influencing BMI-1 expression in immune cells. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Might upregulate BMI-1 in response to hypoxic mimicking conditions. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Hormonal signaling might influence BMI-1 expression in hormone-responsive tissues. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Oxidative stress can modulate several signaling pathways, potentially influencing BMI-1 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Can activate PKC and various signaling pathways, potentially influencing BMI-1 expression. | ||||||
Smoothened Agonist, HCl | 364590-63-6 | sc-202814 sc-202814A | 1 mg 5 mg | $210.00 $520.00 | 31 | |
Activation of Shh signaling has been linked to BMI-1 upregulation in some contexts. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A glucocorticoid that can modulate various cellular responses, potentially influencing BMI-1 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates intracellular cAMP levels, which might influence BMI-1 expression. | ||||||