BMAL2 Inhibitors
BMAL2 inhibitors represent a class of chemical compounds that have attracted interest in the field of molecular biology and circadian rhythm research. These inhibitors are specifically designed to target and modulate the activity of BMAL2, also known as ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2). BMAL2 is a transcription factor protein that is part of the molecular machinery governing the circadian clock, a highly conserved system that regulates daily rhythms in various physiological and behavioral processes. While its role is less well-characterized compared to its homolog, BMAL1 (ARNTL), BMAL2 is believed to contribute to the intricacies of circadian regulation and may have tissue-specific functions.
BMAL2 inhibitors exert their effects by interfering with the transcriptional activity or expression of BMAL2, disrupting its role in the circadian clock. This interference can lead to alterations in the timing and amplitude of circadian gene expression, affecting the synchronization of biological processes with the day-night cycle. Researchers employ BMAL2 inhibitors as valuable tools to investigate the specific functions and regulatory mechanisms of BMAL2 in different tissues and under various conditions. Understanding the contributions of BMAL2 to circadian rhythms is essential for advancing our knowledge of molecular and cellular biology related to biological timing and could have implications for research on sleep disorders, metabolism, and other areas of circadian biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor, which may alter chromatin structure and downregulate transcription of genes like BMAL2. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Another HDAC inhibitor that could potentially modify histones associated with the BMAL2 promoter and reduce its expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that may influence the translation and stability of many proteins, possibly including BMAL2. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
A drug that binds to GC-rich DNA sequences, potentially disrupting transcription factor binding to the BMAL2 promoter. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
An antibiotic that intercalates into DNA, inhibiting RNA polymerase and possibly downregulating BMAL2 transcription. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A selective p300/CBP inhibitor that may affect the acetylation status of histones around the BMAL2 gene, reducing its expression. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $186.00 $674.00 | 10 | |
Disrupts the structure of the chromatin and hinders the transcription of genes involved in the circadian rhythm, including BMAL2. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Inhibits acetaldehyde dehydrogenase and may have off-target effects that alter the expression of proteins like BMAL2. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can cause the accumulation of repressive transcription factors, potentially lowering BMAL2 levels. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
A cyclin-dependent kinase inhibitor that could indirectly affect the phosphorylation state of proteins regulating BMAL2. | ||||||