β-defensin 37 Activators
β-Defensin 37, a crucial component of the innate immune system, plays a pivotal role in antimicrobial defense against a spectrum of pathogens. Functioning as an antimicrobial peptide, it disrupts microbial membranes, exerts bactericidal effects, and strengthens the initial line of defense. The activation of β-defensin 37 involves a sophisticated interplay of cellular signaling pathways influenced by various chemical activators. Compounds such as retinoic acid, thiazolidinediones, sulforaphane, butyrate, genistein, resveratrol, 5-azacytidine, alpha-lipoic acid, luteolin, diallyl disulfide, EGCG, and quercetin exert their effects through specific pathways, ranging from nuclear receptors to epigenetic modifications. These pathways converge at the DEFB37 promoter, leading to enhanced transcription and elevated β-defensin 37 expression.
Understanding these activation mechanisms not only unveils the complexity of innate immunity but also provides insights into potential strategies for modulating β-defensin 37 expression. This knowledge contributes to our comprehension of host-pathogen interactions and may have implications for developing innovative approaches to reinforce the innate immune response against microbial challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates β-defensin 37 by inhibiting the NF-κB pathway. It suppresses IκB kinase activity, preventing IκB degradation and subsequent NF-κB nuclear translocation. This down-regulation of NF-κB alleviates its suppression on DEFB37 transcription, leading to enhanced β-defensin 37 expression with implications for antimicrobial defense. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin stimulates β-defensin 37 indirectly by modulating the AP-1 pathway. It inhibits c-Fos and c-Jun activation, suppressing AP-1 transcriptional activity. As a consequence, the negative regulation on DEFB37 expression is alleviated, leading to increased β-defensin 37 synthesis with antimicrobial implications. | ||||||