Bestrophin-3 Inhibitors are a specific class of chemical compounds that have gained significant attention in the realm of molecular biology and pharmacology due to their role in modulating the activity of the protein bestrophin-3. Bestrophins are a family of ion channels that are primarily found in the cell membranes of various tissues, including the retina, brain, and smooth muscle cells. Among the family members, bestrophin-3 stands out as a particularly important target for inhibition. These inhibitors are designed to interact with bestrophin-3, altering its function or blocking its activity, which can have important implications in various cellular processes.
Bestrophin-3 Inhibitors typically involves binding to the bestrophin-3 protein, thereby preventing it from facilitating the transport of ions across the cell membrane. This inhibition can disrupt the normal cellular processes that rely on bestrophin-3, potentially leading to altered cellular functions and signaling pathways. Researchers are particularly interested in studying the effects of Bestrophin-3 Inhibitors in a variety of cellular contexts to better understand the precise roles of bestrophin-3 in health and disease. By elucidating the molecular mechanisms by which these inhibitors modulate bestrophin-3 activity, scientists aim to gain valuable insights into cellular physiology and potentially identify new avenues for the development of novel strategies in the future. While the specific applications of Bestrophin-3 Inhibitors are beyond the scope of this description, their ability to manipulate bestrophin-3 activity has opened up exciting avenues of research in the field of molecular biology and pharmacology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid is a nonsteroidal anti-inflammatory drug that can inhibit chloride currents in a variety of cells, including those mediated by Bestrophin-3. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic acid is known to block various chloride channels, including Bestrophin-3, by altering the channel conductance. | ||||||
T16Ainh-A01 | 552309-42-9 | sc-497578 sc-497578A | 10 mg 50 mg | $69.00 $283.00 | ||
T16Ainh-A01 is an inhibitor of calcium-activated chloride channels and can inhibit Bestrophin-3 by binding to it and preventing its activation by calcium. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Tannic acid (Gallotannin) has been shown to inhibit various chloride channels, potentially including Bestrophin-3 through non-specific interactions with the channel proteins. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is a modulator of several ion channels and can inhibit Bestrophin-3 by altering the channel's sensitivity to calcium. | ||||||
Carbenoxolone | 5697-56-3 | sc-507294 | 1 g | $50.00 | ||
Carbenoxolone is a gap junction blocker that can indirectly inhibit Bestrophin-3 by modulating cellular calcium levels and signaling pathways. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
Ivermectin, an avermectin, can modulate various ion channels and has been reported to inhibit Bestrophin-3 by binding to its pore region. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole is a benzimidazole that can affect ion channels and has the potential to inhibit Bestrophin-3 indirectly through cellular signaling alterations. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide is an anthelmintic that can inhibit chloride channels including Bestrophin-3 by altering the chloride conductance across the cell membrane. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Glyburide (Glibenclamide) is a sulfonylurea that can inhibit ATP-sensitive potassium channels and potentially affect Bestrophin-3 activity by modulating cellular ionic homeostasis. | ||||||