Date published: 2026-5-18

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Bestrophin-3 Inhibitors

Bestrophin-3 Inhibitors are a specific class of chemical compounds that have gained significant attention in the realm of molecular biology and pharmacology due to their role in modulating the activity of the protein bestrophin-3. Bestrophins are a family of ion channels that are primarily found in the cell membranes of various tissues, including the retina, brain, and smooth muscle cells. Among the family members, bestrophin-3 stands out as a particularly important target for inhibition. These inhibitors are designed to interact with bestrophin-3, altering its function or blocking its activity, which can have important implications in various cellular processes.

Bestrophin-3 Inhibitors typically involves binding to the bestrophin-3 protein, thereby preventing it from facilitating the transport of ions across the cell membrane. This inhibition can disrupt the normal cellular processes that rely on bestrophin-3, potentially leading to altered cellular functions and signaling pathways. Researchers are particularly interested in studying the effects of Bestrophin-3 Inhibitors in a variety of cellular contexts to better understand the precise roles of bestrophin-3 in health and disease. By elucidating the molecular mechanisms by which these inhibitors modulate bestrophin-3 activity, scientists aim to gain valuable insights into cellular physiology and potentially identify new avenues for the development of novel strategies in the future. While the specific applications of Bestrophin-3 Inhibitors are beyond the scope of this description, their ability to manipulate bestrophin-3 activity has opened up exciting avenues of research in the field of molecular biology and pharmacology.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Niflumic acid

4394-00-7sc-204820
5 g
$32.00
3
(1)

Niflumic acid is a nonsteroidal anti-inflammatory drug that can inhibit chloride currents in a variety of cells, including those mediated by Bestrophin-3.

Flufenamic acid

530-78-9sc-205699
sc-205699A
sc-205699B
sc-205699C
10 g
50 g
100 g
250 g
$27.00
$79.00
$154.00
$309.00
1
(1)

Flufenamic acid is known to block various chloride channels, including Bestrophin-3, by altering the channel conductance.

T16Ainh-A01

552309-42-9sc-497578
sc-497578A
10 mg
50 mg
$69.00
$283.00
(0)

T16Ainh-A01 is an inhibitor of calcium-activated chloride channels and can inhibit Bestrophin-3 by binding to it and preventing its activation by calcium.

Gallotannin

1401-55-4sc-202619
sc-202619A
sc-202619B
sc-202619C
sc-202619D
sc-202619E
sc-202619F
1 g
10 g
100 g
250 g
1 kg
2.5 kg
5 kg
$26.00
$37.00
$67.00
$78.00
$234.00
$536.00
$983.00
12
(1)

Tannic acid (Gallotannin) has been shown to inhibit various chloride channels, potentially including Bestrophin-3 through non-specific interactions with the channel proteins.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$28.00
$53.00
37
(1)

2-APB is a modulator of several ion channels and can inhibit Bestrophin-3 by altering the channel's sensitivity to calcium.

Carbenoxolone

5697-56-3sc-507294
1 g
$50.00
(0)

Carbenoxolone is a gap junction blocker that can indirectly inhibit Bestrophin-3 by modulating cellular calcium levels and signaling pathways.

Ivermectin

70288-86-7sc-203609
sc-203609A
100 mg
1 g
$57.00
$77.00
2
(2)

Ivermectin, an avermectin, can modulate various ion channels and has been reported to inhibit Bestrophin-3 by binding to its pore region.

Mebendazole

31431-39-7sc-204798
sc-204798A
5 g
25 g
$46.00
$89.00
2
(2)

Mebendazole is a benzimidazole that can affect ion channels and has the potential to inhibit Bestrophin-3 indirectly through cellular signaling alterations.

Niclosamide

50-65-7sc-250564
sc-250564A
sc-250564B
sc-250564C
sc-250564D
sc-250564E
100 mg
1 g
10 g
100 g
1 kg
5 kg
$38.00
$79.00
$188.00
$520.00
$1248.00
$5930.00
8
(1)

Niclosamide is an anthelmintic that can inhibit chloride channels including Bestrophin-3 by altering the chloride conductance across the cell membrane.

Glyburide (Glibenclamide)

10238-21-8sc-200982
sc-200982A
sc-200982D
sc-200982B
sc-200982C
1 g
5 g
25 g
100 g
500 g
$46.00
$61.00
$117.00
$173.00
$530.00
36
(1)

Glyburide (Glibenclamide) is a sulfonylurea that can inhibit ATP-sensitive potassium channels and potentially affect Bestrophin-3 activity by modulating cellular ionic homeostasis.