Bestrophin-3 Activators
Bestrophin-3 Activators encompass various compounds that indirectly influence the activity of Bestrophin-3, a calcium-activated chloride channel known for its role in ion transport and regulation of cellular volume. Compounds like Calcium Chloride and Ionomycin enhance Bestrophin-3 activity by increasing intracellular calcium concentration, a critical factor for the activation of Bestrophin-3. Calcium plays a pivotal role in regulating Bestrophin-3, enabling it to facilitate chloride ion transport across cell membranes, a process essential for maintaining cellular homeostasis and function. Similarly, EGTA, a calcium chelator, indirectly modulates Bestrophin-3 by altering calcium levels, further emphasizing the importance of calcium in regulating Bestrophin-3 activity. Niflumic Acid and Flufenamic Acid, known as chloride channel blockers, can modulate Bestrophin-3's activity by altering chloride ion flux, which is integral to Bestrophin-3's role in various physiological processes, including ion transport and epithelial cell function.
Additional compounds like 1-Ethyl-2-benzimidazolinone, DIDS, and Genistein affect Bestrophin-3 activity by influencing chloride flux or modulating related signaling pathways. These modifications in ion channel dynamics and cellular signaling impact Bestrophin-3's role in maintaining ion balance and cellular signaling processes. Forskolin, by elevating cAMP levels, indirectly impacts Bestrophin-3, demonstrating the interconnected nature of cellular signaling pathways and ion channel regulation. Glybenclamide, an ATP-sensitive potassium channel inhibitor, and Tannic Acid, with its protein-precipitating effects, may also indirectly influence Bestrophin-3 activity by altering cellular ion dynamics and protein interactions. Verapamil, a calcium channel blocker, further illustrates the intricate relationship between calcium homeostasis and Bestrophin-3 activity. These Bestrophin-3 Activators, through their diverse mechanisms of action, underscore the significance of Bestrophin-3 in ion transport, cellular volume regulation, and overall cellular homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium Chloride can enhance Bestrophin-3 activity by increasing intracellular calcium concentration, which is critical for Bestrophin-3's function as a calcium-activated chloride channel involved in ion transport and cellular volume regulation. | ||||||
1-EBIO | 10045-45-1 | sc-201695 sc-201695A | 10 mg 50 mg | $87.00 $325.00 | 1 | |
1-Ethyl-2-benzimidazolinone, a chloride channel modulator, can indirectly influence Bestrophin-3 activity, potentially affecting its role in chloride ion transport and cellular homeostasis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, may indirectly enhance Bestrophin-3 activity by modulating signaling pathways that influence ion channel function, impacting cellular signaling and homeostasis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin indirectly influences Bestrophin-3 activity by elevating cAMP levels, which can affect various ion channels, including calcium-activated chloride channels like Bestrophin-3. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin, a calcium ionophore, enhances Bestrophin-3 activity by increasing intracellular calcium levels, directly influencing its function as a calcium-activated chloride channel. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, can indirectly affect Bestrophin-3 activity by altering calcium homeostasis, impacting the calcium-dependent activation of Bestrophin-3. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
EGTA, a calcium chelator, may indirectly modulate Bestrophin-3 activity by altering intracellular calcium levels, which are critical for Bestrophin-3's function as a calcium-activated chloride channel. | ||||||