BC052484 Activators
BC052484 activators comprise a diverse array of chemical compounds that indirectly enhance the protein's functional activity through various signaling mechanisms. Forskolin, by increasing cAMP, indirectly supports BC052484 activation via PKA, which phosphorylates substrates potentially involved with BC052484, thus enhancing its functionality. PMA, through PKC activation, and EGCG, by inhibiting competitive kinases, manipulate signaling pathways that could lead to increased BC052484 activity. LY294002, with its inhibitory action on PI3K, and SB203580, through p38 MAPK inhibition, alter signaling dynamics in favor of BC052484 activation. S1P, by activating its receptors, initiates signaling events that might intersect with BC052484's pathways, potentially leading to its enhanced function.
In the cellular milieu, ionophores like Ionomycin and A23187 elevate intracellular calcium levels, which triggers a cascade of calcium-dependent kinases that may indirectly enhance BC052484's activity. Thapsigargin further contributes to this effect by inhibiting the SERCA pump, leading to an increase in intracellular calcium, and consequently, the activation of calcium-dependent pathways that could potentiate BC052484's function. Genistein and Staurosporine, by modulating tyrosine kinase and broad-spectrum kinase activities respectively, may release BC052484 from inhibitory constraints, allowing for enhanced activity. Together, these activators, through their targeted effects on cellular signaling, facilitate the functional enhancement of BC052484 without necessitating upregulation of its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is involved in numerous cellular processes. By activating PKC, PMA could influence signaling pathways that converge on the functional modulation of BC052484. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels, potentially triggering calcium-dependent protein kinases that may indirectly increase the activity of BC052484 by altering the cellular environment in which BC052484 operates. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to function as a kinase inhibitor, and by inhibiting competitive kinase signaling, it may indirectly enhance the functional activity of BC052484 through the release of inhibitory pressures within the cell. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K), which could shift signaling pathways towards those that BC052484 is involved in, thus potentially enhancing BC052484's activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates sphingosine-1-phosphate receptors and can lead to the activation of signaling cascades that may intersect with the functional pathways of BC052484, resulting in an increase in BC052484's activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, which can alter the cellular signaling balance and potentially enhance the functional processes associated with BC052484 by inhibiting competing signaling pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. By inhibiting MEK1/2, U0126 could indirectly support the activation of BC052484 through the reduction of competitive pathway signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in intracellular calcium levels, which can activate calcium-dependent signaling that might enhance BC052484's activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium levels and could thereby activate pathways that enhance the functional activity of BC052484. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that could lead to selective activation of pathways in which BC052484 is involved by inhibiting kinases that negatively regulate these pathways. | ||||||