BBS12 Inhibitors
BBS12 inhibitors are chemical compounds that indirectly reduce the functional activity of BBS12, a protein with a critical role in the structure and function of cilia. For example, Vardenafil, a PDE5 inhibitor, augments intracellular cGMP levels, which may counteract BBS12's role in ciliary signaling and transport, leading to its functional inhibition. Indomethacin, by inhibiting COX and reducing prostaglandin synthesis, potentially affects ciliary beat frequency, which could indirectly impact the function of BBS12. Chloroquine, by disrupting lysosomal acidification, could impair ciliary assembly and maintenance, challenging BBS12's contribution to ciliogenesis. Furthermore, Rapamycin's suppression of the mTOR pathway, which is crucial for ciliogenesis, could result in a reduced functional presence of BBS12 due to decreased ciliogenesis.
Other inhibitors, such as Ciliobrevin D, target dynein and disrupt ciliary trafficking, a process in which BBS12 is directly involved. Cytochalasin D, which disrupts actin filaments, can affect BBS12's role in ciliary processes by altering actin dynamics essential for ciliogenesis. Retinoic acid modifies gene expression affecting ciliary function and structure, which indirectly impacts BBS12's role in these processes. Niclosamide disrupts Wnt signaling, potentially diminishing BBS12's function in ciliogenesis, while Taxol's stabilization of microtubules might indirectly affect BBS12's ciliary function by altering microtubule dynamics. Oligomycin A and MG-132 disrupt ATP levels and the ubiquitin-proteasome pathway, respectively, both essential for ciliary motility and assembly where BBS12 plays a role. Lastly, Lithium chloride's inhibition of GSK-3, a component of the Wnt pathway, could lead to diminished BBS12 activity by affecting the structure and function of cilia. These inhibitors collectively contribute to the reduction of BBS12's functional activity by targeting the pathways and processes fundamental to its role in ciliogenesis and ciliary function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
Phosphodiesterase type 5 (PDE5) inhibitor, Vardenafil increases cGMP levels in cells, which could counteract the function of BBS12 in ciliary transport processes due to altered ciliary signaling, thus potentially diminishing BBS12's functional activity. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Cyclooxygenase (COX) inhibitor, Indomethacin reduces prostaglandin synthesis. Prostaglandins have been implicated in the regulation of ciliary beat frequency in respiratory epithelia, which could indirectly affect ciliary function and thus potentially diminish the functional activity of BBS12, a protein involved in ciliary function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Autophagy inhibitor, Chloroquine impairs lysosome acidification and may disrupt ciliary assembly and maintenance, indirectly leading to a diminishment of BBS12's role in ciliogenesis and ciliary function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor, Rapamycin suppresses mTOR signaling which is essential for ciliogenesis. Since BBS12 is involved in ciliary function, its activity could be indirectly diminished by rapamycin's inhibition of mTOR, leading to a decrease in ciliogenesis. | ||||||
Ciliobrevin D | 1370554-01-0 | sc-507482 | 10 mg | $413.00 | ||
Hedgehog (Hh) signaling inhibitor, Ciliobrevin D directly inhibits dynein, which is crucial for ciliary trafficking. This could diminish the functional activity of BBS12 by disrupting the intracellular transport processes required for ciliary function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Actin polymerization inhibitor, Cytochalasin D disrupts actin filaments which are involved in ciliogenesis and ciliary function. By disrupting actin dynamics, it could indirectly diminish the functional activity of BBS12 which is involved in ciliary processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
By altering gene expression, Retinoic acid could modify the cellular composition required for ciliary function, indirectly affecting the functional activity of BBS12 which is involved in the biogenesis and function of cilia. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Wnt signaling pathway inhibitor, Niclosamide could indirectly diminish BBS12's functional activity by disrupting Wnt signaling, which has been implicated in ciliogenesis and ciliary function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Microtubule stabilizer, Taxol can disrupt microtubule dynamics, which are essential for ciliary function. Since BBS12 is involved in ciliary function, the stability of microtubules influenced by paclitaxel could indirectly lead to a diminishment of BBS12's activity. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
ATP synthase inhibitor, Oligomycin A could diminish BBS12's functional activity by reducing cellular ATP levels, thus potentially affecting ciliary motility and assembly processes that depend on ATP, and where BBS12 plays a role. | ||||||