BAT3 Inhibitors
BAT3 inhibitors are a class of chemical compounds that target and inhibit the activity of BAT3 (BCL2-associated athanogene 6), a protein known for its involvement in cellular processes such as protein folding, stress response, and the regulation of apoptosis. BAT3 is located primarily in the nucleus but can translocate to the cytoplasm under stress conditions. It is a part of the BAG family, which is involved in the regulation of molecular chaperones, including HSP70. Inhibitors of BAT3 interfere with its ability to mediate protein interactions and modulate cellular stress pathways, thereby impacting protein stability and the cellular stress response system. This inhibition can also affect the regulation of apoptosis, as BAT3 plays a role in controlling the balance between pro-apoptotic and anti-apoptotic signals within the cell.
BAT3 inhibitors typically possess structures that allow them to interact directly with specific domains of the BAT3 protein, hindering its functional capabilities. These inhibitors are designed to bind with high affinity to particular regions involved in protein-protein interactions, which can disrupt the normal function of BAT3 in its role as a molecular chaperone regulator. The design and optimization of these inhibitors often involve structure-activity relationship (SAR) studies to enhance selectivity and potency. Their role in modulating cellular processes, particularly in the context of stress responses and protein stability, makes BAT3 inhibitors important tools in understanding the molecular biology of cells and the complex networks of proteins they regulate.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine may decrease methylation levels on the BAT3 gene promoter, leading to its downregulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, as an HDAC inhibitor, might promote acetylation of histone proteins associated with the BAT3 gene, potentially reducing its transcription. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG 108 may lead to demethylation of the BAT3 gene promoter, which could decrease BAT3 gene expression by making the chromatin less accessible to transcriptional machinery. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid could induce hyperacetylation of histones near the BAT3 gene, potentially leading to a closed chromatin conformation and decreased expression of BAT3. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Though a PARP inhibitor, Olaparib could indirectly downregulate BAT3 expression by altering the balance of cellular DNA repair and transcriptional processes. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 may disrupt the interaction between MDM2 and p53, enhancing p53 activity, which could lead to the downregulation of BAT3 expression as part of a stress response. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram may interfere with metalloprotein activity that is indirectly necessary for the transcriptional activation of the BAT3 gene, leading to its decreased expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
By binding to retinoic acid receptors, Retinoic acid may alter the transcriptional activity of genes including BAT3, potentially leading to its downregulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, by inhibiting tyrosine kinases, may disrupt signal transduction pathways that are crucial for the maintenance of BAT3 gene expression, thereby reducing its levels. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A may bind to GC-rich sequences in the DNA, potentially blocking the binding of transcriptional activators to the BAT3 promoter, leading to decreased expression. | ||||||