Date published: 2026-3-3

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AVP Receptor V1a Activators

The AVP receptor V1a, a member of the vasopressin receptor family, plays a crucial role in mediating the physiological effects of arginine vasopressin (AVP) in various tissues and organs. Functionally, the AVP receptor V1a is a G protein-coupled receptor (GPCR) primarily expressed in vascular smooth muscle cells, where it regulates vascular tone and blood pressure. Activation of the AVP receptor V1a initiates signaling cascades that culminate in vasoconstriction, leading to increased peripheral vascular resistance and elevation of blood pressure. Additionally, the AVP receptor V1a is also expressed in the central nervous system, where it modulates social behaviors, aggression, and stress responses. Through its role in mediating the effects of AVP, the AVP receptor V1a contributes to the regulation of cardiovascular homeostasis and the modulation of behavioral responses to social and environmental stimuli.Activation of the AVP receptor V1a involves a series of signaling events initiated upon ligand binding, leading to downstream cellular responses. Upon binding of AVP to the AVP receptor V1a, conformational changes occur in the receptor, facilitating the coupling of the receptor to heterotrimeric G proteins. This interaction activates the G protein, leading to the dissociation of the Gα subunit from the Gβγ subunits and subsequent activation of downstream signaling pathways. Activation of phospholipase C (PLC) by Gα initiates the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 triggers the release of calcium ions (Ca2+) from intracellular stores, leading to smooth muscle contraction, while DAG activates protein kinase C (PKC), which further modulates cellular responses. Additionally, Gβγ subunits may activate other signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway, contributing to the diverse cellular effects mediated by the AVP receptor V1a. Understanding the mechanisms underlying AVP receptor V1a activation provides insights into its physiological functions and offers targets for intervention in conditions associated with dysregulated vasopressin signaling.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Felypressin Acetate

914453-97-7sc-497815
5 mg
$380.00
(0)

Felypressin Acetate acts as a selective agonist for the AVP receptor V1A, engaging in specific molecular interactions that stabilize receptor activation. Its binding induces conformational changes that enhance G-protein coupling, leading to distinct intracellular signaling pathways. The compound's unique structure facilitates interactions with membrane lipids, influencing receptor localization and activity. This modulation of signaling dynamics plays a crucial role in various physiological processes.

Desmopressin

16679-58-6sc-391126
1 mg
$138.00
(0)

A synthetic analog of AVP, Desmopressin mimics the endogenous ligand's action and directly activates AVP Receptor V1a. This activation results in the modulation of cellular responses associated with AVP Receptor V1a signaling pathways.

Lypressin

50-57-7sc-279284
5 mg
$190.00
(0)

Lypressin, a synthetic vasopressin analog, directly activates AVP Receptor V1a, initiating intracellular events that modulate cellular processes associated with the receptor. The activation of AVP Receptor V1a by Lypressin mirrors the endogenous ligand′s action.

Vasopressin

11000-17-2sc-356188
sc-356188A
5 mg
25 mg
$260.00
$1040.00
1
(0)

Vasopressin, an endogenous hormone, directly activates AVP Receptor V1a, influencing downstream signaling pathways. The binding of Vasopressin to the receptor leads to the modulation of cellular processes associated with AVP Receptor V1a activation.

Phorbol-12,13-dibutyrate

37558-16-0sc-202285
1 mg
$124.00
3
(1)

A diacylglycerol (DAG) analog that activates protein kinase C (PKC), influencing pathways linked to AVP Receptor V1a. The activation of PKC can modulate downstream signaling cascades, indirectly promoting AVP Receptor V1a activity through PKC-mediated pathways.

Prostaglandin F

551-11-1sc-203219
1 mg
$88.00
1
(1)

An endogenous prostaglandin that can activate phospholipase C (PLC), indirectly influencing AVP Receptor V1a. Activation of PLC can modulate downstream signaling cascades, leading to alterations in cellular processes associated with AVP Receptor V1a activation.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

An inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), indirectly influencing AVP Receptor V1a. Inhibition of SERCA leads to disruption in calcium homeostasis, potentially modulating cellular responses associated with AVP Receptor V1a activation.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

A selective inhibitor of mitogen-activated protein kinase kinase (MEK), indirectly influencing AVP Receptor V1a. Inhibition of MEK disrupts the MAPK signaling pathway, potentially modulating cellular responses associated with AVP Receptor V1a activation.

YM 254890

568580-02-9sc-507356
1 mg
$510.00
(0)

A Gq protein inhibitor that indirectly influences AVP Receptor V1a signaling. Inhibition of Gq proteins can impact downstream pathways, potentially leading to alterations in cellular processes associated with AVP Receptor V1a activation.