ATP6E1 Activators
Chemical activators of ATP6E1 can engage in a range of molecular interactions that bolster the protein's function within the vacuolar ATPase (V-ATPase) complex, essential for proton transport across cellular membranes. Compounds like Benzamidine and N-Ethylmaleimide inhibit proteases that would otherwise degrade V-ATPase subunits, thereby maintaining the structural integrity of ATP6E1 and ensuring its continued activity in proton pumping. Similarly, the presence of Zinc Chloride may enhance ATP6E1 activity by stabilizing its structure through allosteric modulation.
On another front, inhibitors of V-ATPase like Bafilomycin A1 and Concanamycin A, despite their inhibitory action, can induce a cellular compensatory response that upregulates the activity of other V-ATPase complexes, potentially including those containing ATP6E1, to preserve cellular pH balance. Oligomycin A, an ATP synthase inhibitor, can lead to an increase in cellular ATP levels, which indirectly supports ATP6E1 by providing more of the substrate it requires for proton transport. Ionophores and protonophores such as Monensin, Nigericin, Valinomycin, DCCD, and FCCP disrupt ion gradients and mitochondrial functions, which can trigger cellular mechanisms to enhance the activity of V-ATPases containing ATP6E1 in a bid to restore ionic and pH homeostasis. Through these diverse molecular mechanisms, each chemical contributes to the sustained activity of ATP6E1 within its native cellular context.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
Benzamidine is a known inhibitor of serine proteases. As ATP6E1 is a subunit of the vacuolar ATPase (V-ATPase) complex involved in proton transport, the inhibition of serine proteases can prevent the degradation of V-ATPase components, thereby maintaining ATP6E1 activity and ensuring continued proton pumping function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of the V0 subunit of V-ATPases. By inhibiting this subunit, it can lead to compensatory cellular mechanisms that enhance the function of remaining active V-ATPase complexes, including those containing ATP6E1, to sustain proton gradient and cellular pH homeostasis. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $65.00 $162.00 $650.00 $2550.00 | 109 | |
Concanamycin A, like Bafilomycin A1, is a V-ATPase inhibitor that can cause cells to upregulate other proton pumps or V-ATPase complexes in response, potentially leading to increased activity of unaffected ATP6E1-containing complexes. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin A is an inhibitor of ATP synthase. Its action can cause an increase in cellular ATP levels, which can indirectly enhance ATP6E1 activity by providing more substrate for the proton pumping activity of V-ATPases. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions act as allosteric modulators of many enzymes and may stabilize the structure of ATP6E1 within the V-ATPase complex, promoting its activity and effective proton transport. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-Ethylmaleimide irreversibly inhibits cysteine proteases, which might otherwise degrade V-ATPase subunits; this inhibition can promote the stability and activity of ATP6E1 within the V-ATPase complex. | ||||||
DCC | 538-75-0 | sc-239713 sc-239713A | 25 g 100 g | $71.00 $204.00 | 3 | |
DCCD is a protonophore and ATPase inhibitor that can bind to proton channels, potentially causing a compensatory upregulation of other proton pumps, including V-ATPase containing ATP6E1, to maintain proton transport and pH balance. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP uncouples oxidative phosphorylation by transporting protons across membranes, which can lead to an increase in the activity of proton pumps like V-ATPases to compensate, thereby stimulating the function of ATP6E1. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts intracellular ion gradients. Cells may respond by upregulating V-ATPase activity to restore gradients, indirectly enhancing the activity of ATP6E1-containing complexes. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $45.00 $110.00 $235.00 $6940.00 $26879.00 | 9 | |
Nigericin acts as a potassium/hydrogen antiporter and can disrupt proton gradients, similar to Monensin, potentially leading to increased ATP6E1 activity as part of a cellular compensatory mechanism to maintain pH homeostasis. | ||||||