ATF-5 Activators
Activating Transcription Factor 5 (ATF-5) is a member of the ATF/CREB family of transcription factors, playing a critical role in cellular stress response, survival, and differentiation. It is ubiquitously expressed across various tissues, with notable roles in the nervous system, where it supports neuronal survival and function. ATF-5 is involved in regulating the expression of genes critical for cellular adaptation to environmental stresses, such as nutrient deprivation or oxidative stress, and contributes to the maintenance of cellular homeostasis. Its activation is pivotal for the initiation of transcriptional programs that promote cell survival under adverse conditions, making it a key player in determining cell fate during stress responses. Furthermore, ATF-5 is implicated in the regulation of proliferation and differentiation in several cell types, including its role in the development and maintenance of cancer cells, highlighting its importance in both physiological and pathological processes.
The activation of ATF-5 is mediated through various signaling pathways that respond to cellular stress and environmental cues. One primary mechanism involves the integrated stress response (ISR), where ATF-5 is upregulated in response to endoplasmic reticulum (ER) stress, amino acid deprivation, or oxidative stress. This upregulation is typically mediated through the activation of upstream kinases, such as PERK (protein kinase RNA-like endoplasmic reticulum kinase), which phosphorylate eukaryotic initiation factor 2α (eIF2α), leading to an attenuation of general protein synthesis but selective translation of ATF-5 mRNA. Additionally, other signaling molecules, including the mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), can influence ATF-5 activity by modulating its expression levels or promoting its nuclear translocation, thereby affecting its transcriptional activity. The activation of ATF-5 enables cells to initiate specific gene expression programs that support adaptation and survival under stress conditions. This complex regulatory network ensures that ATF-5 activation is tightly controlled, allowing cells to efficiently respond to and survive environmental challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of the TGF-β type I receptor. By blocking TGF-β signaling, SB431542 can indirectly activate ATF-5, as ATF-5 expression is negatively regulated by TGF-β. Inhibition of this pathway releases the repression on ATF-5, allowing for increased ATF-5 expression and activity. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
Also called SC79, this compound is an Akt activator that promotes Akt phosphorylation and activation. Akt is a kinase upstream of mTORC1, a pathway that regulates ATF-5. Activating Akt with SC79 can enhance mTORC1 signaling, leading to the activation of ATF-5 as a downstream target of mTORC1. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720, also known as fingolimod, is an agonist for sphingosine-1-phosphate (S1P) receptors. Activation of S1P receptors can modulate cellular processes, including those related to ATF-5. The specific mechanisms by which S1P receptor activation influences ATF-5 require further elucidation, but its potential role in ATF-5 activation is suggested by its impact on cellular signaling. | ||||||
P276-00 | 920113-03-7 | sc-477932 | 1 mg | $380.00 | ||
P276-00 is a cyclin-dependent kinase (CDK) inhibitor. Inhibition of CDKs can lead to cell cycle arrest and activation of ATF-5. ATF-5 expression is regulated during the cell cycle, and modulation of CDK activity by P276-00 can influence ATF-5 transcription, providing a direct means of activating ATF-5 through cell cycle control. | ||||||
GW 0742 | 317318-84-6 | sc-203991 sc-203991A | 10 mg 50 mg | $190.00 $815.00 | 11 | |
GW0742 is a selective agonist for peroxisome proliferator-activated receptor delta (PPARδ). PPARδ activation can modulate cellular processes involved in ATF-5 regulation. The specific interactions between PPARδ and ATF-5 require further exploration, but the potential for GW0742 to activate ATF-5 through PPARδ signaling presents an intriguing avenue for investigation. | ||||||
Compound 401 | 168425-64-7 | sc-202552 | 5 mg | $75.00 | 4 | |
Compound 401 is a potent and selective activator of the unfolded protein response (UPR). ATF-5 is involved in UPR signaling, and the activation of UPR by Compound 401 can influence ATF-5 expression and activity. The UPR-mediated ATF-5 activation represents a direct mechanism through which this compound can modulate ATF-5 function. | ||||||
A-1210477 | 1668553-26-1 | sc-507474 | 5 mg | $195.00 | ||
A-1210477 is a selective MCL-1 inhibitor. By inhibiting MCL-1, A-1210477 can induce ER stress and activate the unfolded protein response (UPR). ATF-5 is a downstream target of UPR, and its activation in response to ER stress induced by A-1210477 represents an indirect means of activating ATF-5 through UPR signaling pathways. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is an eIF2α dephosphorylation inhibitor. By inhibiting eIF2α dephosphorylation, Salubrinal induces ER stress and activates the unfolded protein response (UPR). ATF-5 is a downstream target of UPR, and its activation in response to ER stress induced by Salubrinal provides an indirect means of activating ATF-5 through UPR signaling pathways. | ||||||
4E1RCat | 328998-25-0 | sc-361085 sc-361085A | 10 mg 50 mg | $189.00 $797.00 | ||
4E1RCat is an eIF4E/eIF4G interaction inhibitor. By disrupting the eIF4E/eIF4G complex, 4E1RCat inhibits cap-dependent translation initiation. ATF-5 is translationally regulated, and the inhibition of cap-dependent translation by 4E1RCat can impact ATF-5 protein levels, providing a direct means of modulating ATF-5 activity at the post-transcriptional level. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
Also called BIO, this compound is a glycogen synthase kinase-3 (GSK-3) inhibitor. ATF-5 is known to be regulated by GSK-3, and inhibition of GSK-3 by BIO can activate ATF-5 through interference with GSK-3-mediated phosphorylation events and subsequent regulatory mechanisms governing ATF-5 function. The activation of ATF-5 by BIO represents a direct mechanism through GSK-3 inhibition. | ||||||