AT1 Inhibitors
Items 11 to 17 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valsartan-d3 | 1331908-02-1 | sc-220363 | 1 mg | $394.00 | ||
Valsartan-d3, a deuterated derivative, showcases unique interactions with the AT1 receptor, characterized by altered isotopic effects that enhance its binding affinity. The presence of deuterium modifies the vibrational frequencies of the molecule, impacting its thermodynamic properties and reaction kinetics. This alteration facilitates distinct conformational states, allowing for nuanced exploration of receptor dynamics and signaling pathways, thereby enriching the understanding of receptor-ligand interactions. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $39.00 $90.00 $120.00 | 4 | |
Valsartan, an angiotensin II receptor blocker, exhibits unique molecular interactions with the AT1 receptor through its specific binding conformation. Its structure allows for selective inhibition of receptor activation, influencing downstream signaling cascades. The compound's hydrophobic regions enhance its affinity for the receptor, while its stereochemistry plays a crucial role in modulating receptor conformational changes. This intricate interplay contributes to the understanding of receptor selectivity and ligand efficacy. | ||||||
Olmesartan Medoxomil | 144689-63-4 | sc-219482 sc-219482A | 10 mg 100 mg | $60.00 $186.00 | ||
Olmesartan Medoxomil, an angiotensin II receptor antagonist, demonstrates distinctive binding characteristics with the AT1 receptor, primarily through its unique spatial arrangement. The compound's ability to form hydrogen bonds and hydrophobic interactions facilitates a strong affinity for the receptor, influencing its activation state. Additionally, the compound's prodrug nature allows for metabolic conversion, enhancing its bioavailability and interaction dynamics within biological systems. This multifaceted behavior underscores its role in receptor modulation. | ||||||
Candesartan Celexetil Ester | 145040-37-5 | sc-204666 sc-204666A | 100 mg 250 mg | $115.00 $200.00 | ||
Candesartan Celexetil Ester exhibits a unique interaction profile with the AT1 receptor, characterized by its lipophilic structure that enhances membrane permeability. The compound's ester functionality allows for selective hydrolysis, leading to the active form that engages in specific ionic and hydrophobic interactions with the receptor. This selective binding alters receptor conformation, influencing downstream signaling pathways and contributing to its distinct pharmacokinetic properties. | ||||||
Azilsartan | 147403-03-0 | sc-503231 sc-503231A sc-503231B sc-503231C sc-503231D sc-503231E | 10 mg 50 mg 100 mg 250 mg 500 mg 1 g | $140.00 $180.00 $230.00 $370.00 $490.00 $781.00 | ||
Azilsartan inhibits AT1 by competitively binding to the angiotensin II receptor, preventing the activation of downstream signaling pathways involved in vasoconstriction and aldosterone release. | ||||||
EMD 66684 | 187683-79-0 | sc-203941 sc-203941A | 10 mg 50 mg | $179.00 $760.00 | ||
EMD 66684 is an innovative compound that acts as an AT1 receptor antagonist, distinguished by its unique molecular architecture that promotes strong binding affinity. Its halide substituents facilitate rapid electrophilic interactions, enhancing reactivity with nucleophiles. The compound's dynamic conformation allows for effective modulation of receptor activity, influencing intracellular signaling cascades. Additionally, its solubility characteristics enable efficient distribution within biological systems, impacting its overall efficacy. | ||||||
N-[(2′-Cyano[1,1′-biphenyl]-4-yl)methyl]-L-valine Methyl Ester Hydrochloride | 482577-59-3 | sc-397092 | 1 g | $320.00 | ||
N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-L-valine Methyl Ester Hydrochloride exhibits intriguing properties as an AT1 receptor antagonist. Its structural design features a cyano group that enhances electron-withdrawing capabilities, promoting specific interactions with receptor sites. The compound's ester functionality contributes to its stability and reactivity, allowing for selective hydrolysis under physiological conditions. This unique profile influences its kinetic behavior, facilitating targeted modulation of signaling pathways. | ||||||