Molecular structure of EMD 66684, CAS Number: 187683-79-0
EMD 66684 (CAS 187683-79-0)
Application:
EMD 66684 is a potent non-peptidic antagonist of the AT1 receptor
CAS Number:
187683-79-0
Molecular Weight:
547.05
Molecular Formula:
C28H30N8O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
EMD 66684 is a potent, selective nonpeptide AT1 receptor antagonist. This compound prevents the binding of angiotensin II to the receptor, which blocks the signal cascade that induces vasoconstricition.
EMD 66684 (CAS 187683-79-0) References
- Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats. | Byku, M., et al. 2008. Am J Physiol Heart Circ Physiol. 295: H2188-97. PMID: 18835922
- Cellular repressor E1A-stimulated genes controls phenotypic switching of adventitial fibroblasts by blocking p38MAPK activation. | Li, Y., et al. 2012. Atherosclerosis. 225: 304-14. PMID: 23040447
- Interactions of neuropeptide y, catecholamines, and angiotensin at the vascular neuroeffector junction. | Westfall, TC., et al. 2013. Adv Pharmacol. 68: 115-39. PMID: 24054142
- Lipid rafts are required for signal transduction by angiotensin II receptor type 1 in neonatal glomerular mesangial cells. | Adebiyi, A., et al. 2014. Exp Cell Res. 324: 92-104. PMID: 24662198
- Systematic characterization of AT1 receptor antagonists with label-free dynamic mass redistribution assays. | Qu, L., et al. 2020. J Pharmacol Toxicol Methods. 102: 106682. PMID: 32087363
- Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. | Mederski, WW., et al. 1994. J Med Chem. 37: 1632-45. PMID: 8201597
Inhibitor of:
AT1, Elmo1, and VE-cadherin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EMD 66684, 10 mg | sc-203941 | 10 mg | $179.00 | |||
EMD 66684, 50 mg | sc-203941A | 50 mg | $760.00 |