ASB-12 Inhibitors
ASB-12 inhibitors work by influencing the ubiquitin-proteasome system and related protein degradation pathways. This is because ASB-12 is an E3 ubiquitin ligase, and its main function is to mark proteins for degradation via the proteasome. Bortezomib, MG-132, Epoxomicin, and Lactacystin are all proteasome inhibitors. They inhibit the proteasome, preventing the degradation of ubiquitinated proteins and thereby disrupting the balance of protein turnover regulated by ASB-12. On the other hand, MLN4924, a NEDD8-activating enzyme inhibitor, hinders the modification of cullin proteins, which are part of the Cullin-RING E3 ubiquitin ligases that ASB-12 is a member of, thus leading to decreased activity of ASB-12.
Certain inhibitors target the ubiquitination process itself to indirectly affect the function of ASB-12. PYR-41, an irreversible inhibitor of ubiquitin-activating enzyme E1, hampers the initiation of ubiquitination. This results in ASB-12 being unable to mark proteins for degradation, as ubiquitination is an essential initiation step. PR-619 is a broad-spectrum deubiquitinase inhibitor that obstructs the removal of ubiquitin from proteins, disrupting the balance of ubiquitination and deubiquitination. This can inhibit ASB-12's function, as deubiquitination is a necessary step in the degradation of proteins marked by ASB-12. Other inhibitors like Chloroquine, Eeyarestatin I, Auranofin, and Leupeptin influence various processes like lysosomal function, endoplasmic reticulum-associated degradation, oxidative stress, and protease activity respectively to indirectly affect the function of ASB-12.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor, which inhibits the degradation of proteins marked for destruction by ubiquitin. This directly interferes with the function of ASB-12, which is an E3 ubiquitin ligase and marks proteins for degradation via the proteasome. This action disrupts the balance of protein turnover regulated by ASB-12. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Like Bortezomib, MG-132 is a proteasome inhibitor. By inhibiting the proteasome, MG-132 disrupts the protein degradation process. Considering that ASB-12 is an E3 ubiquitin ligase and is involved in marking proteins for proteasomal degradation, the action of MG-132 can lead to the inhibition of ASB-12's role in protein turnover. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a specific proteasome inhibitor, meaning it blocks the degradation of proteins marked by ubiquitination. As ASB-12 is an E3 ubiquitin ligase and marks proteins for degradation, the action of Epoxomicin can inhibit the function of ASB-12 by disrupting protein degradation. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme inhibitor. NEDD8 is a ubiquitin-like protein that modifies cullin proteins, which are part of the Cullin-RING E3 ubiquitin ligases that ASB-12 is a member of. By inhibiting NEDD8, MLN4924 can disrupt the function of ASB-12, leading to decreased activity. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
PYR-41 is an irreversible inhibitor of ubiquitin-activating enzyme E1, which is involved in the first step of the ubiquitination process. By inhibiting the initiation of ubiquitination, PYR-41 indirectly affects the function of ASB-12, as it cannot mark proteins for degradation without ubiquitination. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum deubiquitinase inhibitor. It inhibits the removal of ubiquitin from proteins, disrupting the balance of ubiquitination and deubiquitination. This imbalance can inhibit ASB-12's function, as the removal of ubiquitin is a necessary step in the degradation of proteins marked by ASB-12. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific proteasome inhibitor that can inhibit protein degradation. As ASB-12 is an E3 ubiquitin ligase that marks proteins for degradation, the action of Lactacystin can disrupt the function of ASB-12. | ||||||
Chloroquine Sulphate | 132-73-0 | sc-337629 | 25 mg | $224.00 | 2 | |
Chloroquine disrupts lysosomal function by altering intracellular pH. This can inhibit the degradation of proteins marked for destruction by ASB-12, as lysosomes are involved in the degradation of these proteins. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Eeyarestatin I is an inhibitor of the endoplasmic reticulum-associated degradation (ERAD) pathway. By inhibiting ERAD, Eeyarestatin I can disrupt the balance between protein synthesis and degradation, potentially inhibiting the function of ASB-12. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a Thioredoxin reductase inhibitor. This enzyme is vital for maintaining the reduced state of many proteins. Its inhibition can lead to oxidative stress and affect the function of many proteins, including ASB-12. | ||||||