ARID1A Inhibitors

ARID1A inhibitors belong to a chemical class that targets the AT-rich interaction domain 1A (ARID1A) protein. ARID1A is a component of the chromatin remodeling complex known as the switch/sucrose non-fermentable (SWI/SNF) complex. This complex plays a pivotal role in regulating gene expression by altering the structure of chromatin, thus influencing the accessibility of DNA to transcription factors and other regulatory elements.

Inhibitors of ARID1A are designed to modulate the activity of this protein by interfering with its interactions within the SWI/SNF complex or its binding to specific DNA regions. By doing so, these inhibitors may impact gene expression patterns and cellular processes that are governed by the SWI/SNF complex, leading to downstream effects on cell proliferation, differentiation, and other functions. Research into ARID1A inhibitors contributes to a deeper understanding of the molecular mechanisms underlying chromatin remodeling and gene regulation, and it opens up avenues for exploring new strategies to manipulate cellular processes for various purposes.