Date published: 2026-4-20

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Arginase Inhibitors

Santa Cruz Biotechnology now offers a broad range of Arginase Inhibitors for use in various applications. Arginase inhibitors are a crucial category of compounds in scientific research, particularly in the study of nitrogen metabolism and the urea cycle. Arginase is an enzyme that catalyzes the hydrolysis of arginine into ornithine and urea, a key step in the detoxification of ammonia in the liver. By inhibiting arginase, researchers can explore its role in various metabolic pathways, particularly those involved in amino acid metabolism and nitric oxide production. These inhibitors are invaluable in studies aimed at understanding the regulation of arginine availability, which is essential for protein synthesis and the production of polyamines, proline, and other metabolites. Arginase inhibitors are also used to investigate the enzyme's role in modulating nitric oxide levels, as arginine is a common substrate for both arginase and nitric oxide synthase. The inhibition of arginase allows for increased availability of arginine for nitric oxide production, providing insights into how this balance affects various physiological processes. Additionally, these inhibitors are employed in research exploring the broader implications of arginase activity in areas such as immunology, where the enzyme plays a role in immune cell function and inflammation. The availability of a diverse range of arginase inhibitors enables researchers to tailor their experimental approaches to specific aspects of arginase function, advancing our understanding of its role in cellular metabolism and its potential impact on various biological systems. View detailed information on our available Arginase Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(2S)-(+)-Amino-5-iodoacetamidopentanoic acid

35748-65-3sc-202409
sc-202409A
5 mg
25 mg
$209.00
$413.00
(0)

(2S)-(+)-Amino-5-iodoacetamidopentanoic acid functions as a selective arginase inhibitor, characterized by its ability to form specific ionic interactions with key residues in the enzyme's active site. This compound stabilizes a unique conformation of arginase, effectively modulating its catalytic efficiency. Its structural features promote distinct conformational shifts, impacting substrate binding and turnover rates, while its solubility profile allows for effective integration into various biochemical assays.

NG-Hydroxy-L-arginine, Monoacetate Salt

53598-01-9sc-222067A
sc-222067
5 mg
25 mg
$109.00
$395.00
(0)

NG-Hydroxy-L-arginine, Monoacetate Salt acts as an arginase modulator, exhibiting unique binding dynamics that influence enzyme activity. Its hydroxyl group facilitates hydrogen bonding with critical amino acids in the active site, enhancing substrate affinity. This compound also alters the enzyme's conformational landscape, leading to variations in reaction kinetics. Additionally, its acetate moiety contributes to solubility, enabling diverse interactions in biochemical environments.

(2S)-(+)-Amino-6-iodoacetamidohexanoic acid

90764-56-0sc-220847
5 mg
$204.00
(0)

(2S)-(+)-Amino-6-iodoacetamidohexanoic acid functions as an arginase inhibitor, characterized by its ability to form stable complexes with the enzyme's active site. The presence of the iodoacetamido group introduces steric hindrance, which modulates substrate access and alters catalytic efficiency. This compound's unique structural features promote specific electrostatic interactions, influencing the enzyme's conformational stability and overall reactivity in metabolic pathways.