(2S)-(+)-Amino-5-iodoacetamidopentanoic acid, also known as 2-AIPA, is an irreversible inhibitor of ODC (ornithine decarboxylase) and arginase. Both (2S)-(+)-Amino-5-iodoacetamidopentanoic acid and (2S)-(+)-Amino-6-iodoacetamidohexanoic acid (sc-220847) are demonstrated to produce antitumor effects in rat and mice studies, decreasing total serum proteins and increasing ALT and AST levels in these models.
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