Apg-2 (HSPA4) Activators
Apg-2 (also known as HSPA4) activators represent a class of compounds that have been investigated for their ability to modulate the activity of the heat shock protein Apg-2, a member of the HSP70 family. Apg-2, or HSPA4, plays a crucial role as a molecular chaperone within cells, participating in protein folding, stability, and cellular stress responses. This class of activators is characterized by their capacity to enhance the chaperone functions of Apg-2, thereby influencing various cellular processes related to protein homeostasis.
HSP90 inhibitors and chemical chaperones are part of a broader class of compounds that target protein folding and stress responses. Their mechanisms of action vary, but they can all indirectly influence the expression and activity of heat shock proteins like HSPA4 by modulating cellular proteostasis and stress pathways. It's important to note that the effects of these compounds can vary depending on cell type and context, and their applications are being explored in various diseases, including cancer and neurodegenerative disorders. Heat Shock Protein 90 (HSP90) inhibitors and chemical chaperones can indirectly affect HSPA4 (Heat Shock Protein Family A Member 4) expression and function by modulating cellular stress responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin and its derivatives, such as 17-AAG (17-Allylamino-17-demethoxygeldanamycin) and 17-DMAG (17-Dimethylaminoethylamino-17-demethoxygeldanamycin), are potent HSP90 inhibitors. These compounds disrupt the chaperone function of HSP90 and lead to the destabilization and degradation of client proteins, triggering cellular stress responses that can indirectly impact HSPA4 expression. | ||||||
Ganetespib | 888216-25-9 | sc-364496 sc-364496A | 10 mg 250 mg | $273.00 $1040.00 | ||
Ganetespib is a second-generation HSP90 inhibitor with clinical potential. It binds to HSP90 and inhibits its ATPase activity, resulting in the degradation of client proteins and the activation of cellular stress responses. | ||||||
NVP-AUY922 | 747412-49-3 | sc-364551 sc-364551A sc-364551B sc-364551C sc-364551D sc-364551E | 5 mg 25 mg 100 mg 250 mg 1 g 5 g | $150.00 $263.00 $726.00 $1400.00 $2900.00 $11000.00 | 3 | |
NVP-AUY922 is another HSP90 inhibitor that competes with ATP for binding to HSP90, leading to the degradation of client proteins. This can trigger the induction of heat shock proteins like HSPA4. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
TUDCA is a chemical chaperone that has been investigated for its ability to stabilize protein folding and reduce cellular stress. It has been shown to protect against endoplasmic reticulum (ER) stress and may indirectly influence the expression and function of HSPA4. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-PBA is another chemical chaperone that can alleviate ER stress by promoting proper protein folding. It has been studied for its potential therapeutic applications in diseases associated with protein misfolding and ER stress. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
PB is a prodrug of 4-PBA and has similar chemical chaperone properties. It can mitigate ER stress and protein misfolding. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose is a natural disaccharide that acts as a chemical chaperone. It stabilizes proteins and helps maintain their native conformation, potentially reducing cellular stress responses and indirectly affecting HSPA4 expression. | ||||||