AP1S3 Inhibitors
AP1S3 inhibitors are chemical compounds that directly or indirectly influence the function of AP1S3, a subunit of the adaptor protein complex 1, which is involved in clathrin-coated vesicle assembly and intracellular trafficking. Inhibitors such as Brefeldin A, Dynasore, Exo1, and Pitstop 2 act by disrupting protein transport and vesicle formation, thereby indirectly impeding the assembly and function of vesicles involving AP1S3. For instance, Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus, and Dynasore inhibits the function of dynamin, a GTPase necessary for vesicle formation and release. This inhibition can result in decreased functional activity of AP1S3 by inhibiting it from participating in these processes.
Other inhibitors such as Monensin, Nocodazole, Wortmannin, LY294002, Vinblastine, Genistein, Chlorpromazine, and Latrunculin B disrupt intracellular trafficking, microtubule dynamics, and intracellular signaling, which can also lead to decreased functional activity of AP1S3. For instance, Monensin alters ion gradients to disrupt intracellular trafficking, while Nocodazole and Vinblastine disrupt the microtubule dynamics necessary for vesicle transport. Wortmannin and LY294002 inhibit the PI3K-dependent pathway, compromising vesicle trafficking. Genistein, a tyrosine kinase inhibitor, can disrupt intracellular signaling, which indirectly affects vesicle formation and trafficking. Chlorpromazine inhibits clathrin-mediated endocytosis, and Latrunculin B binds to actin monomers to inhibit polymerization, both of which can disrupt vesicle trafficking. Through these mechanisms, the functional activity of AP1S3 can be effectively decreased.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a fungal metabolite that inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus. The inhibition of protein transport can indirectly affect AP1S3's role in the formation of clathrin-coated vesicles by preventing the delivery of necessary proteins to the Golgi. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is an inhibitor of dynamin, a GTPase involved in vesicle formation. Dynasore's inhibition of dynamin can disrupt the formation and release of clathrin-coated vesicles from the membrane, a process in which AP1S3 is involved, potentially leading to decreased functional activity of AP1S3. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $84.00 $297.00 | 4 | |
Exo1 is an inhibitor of exocyst complex function. The inhibition of the exocyst complex by Exo1 can disrupt vesicle trafficking, a process in which AP1S3 is involved, leading to a decrease in AP1S3's functional activity. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin-mediated endocytosis. As AP1S3 is involved in the formation of clathrin-coated vesicles, Pitstop 2's inhibition of clathrin-mediated endocytosis can decrease the functional activity of AP1S3. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin, a sodium ionophore, disrupts intracellular trafficking by altering ion gradients. Given AP1S3's role in vesicle trafficking, this alteration can impact AP1S3's activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent. As AP1S3 is involved in vesicle transport along microtubules, Nocodazole's depolymerization of microtubules can disrupt this transport process, leading to decreased functional activity of AP1S3. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that can disrupt vesicle trafficking by inhibiting the PI3K-dependent pathway. As AP1S3 is involved in vesicle trafficking, Wortmannin's inhibition of PI3K can lead to decreased functional activity of AP1S3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can disrupt vesicle trafficking by inhibiting the PI3K-dependent pathway. As AP1S3 is involved in vesicle trafficking, LY294002's inhibition of PI3K can lead to decreased functional activity of AP1S3. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $109.00 $412.00 $561.00 $2244.00 | 9 | |
Vinblastine is a microtubule-disrupting agent that inhibits microtubule dynamics, leading to the disruption of vesicle transport along the microtubules. Since AP1S3 is involved in vesicle transport, the disruption of microtubule dynamics by Vinblastine can lead to decreased functional activity of AP1S3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can disrupt intracellular signaling, which can indirectly influence vesicle formation and trafficking. As AP1S3 is involved in vesicle trafficking, the inhibition of tyrosine kinase by Genistein can lead to decreased functional activity of AP1S3. | ||||||