AP-4 Inhibitors
The chemical class of AP-4 inhibitors is a theoretical grouping of compounds that would affect the Adaptor Protein complex 4 (AP-4) indirectly. Since direct inhibitors of AP-4 are not well-defined, this class includes a variety of chemical compounds that influence cellular processes or signaling pathways related to AP-4's function. These chemicals span multiple classes, including kinase inhibitors, vesicular transport disruptors, and microtubule affecting agents.
Each chemical listed operates within a unique mechanism, affecting various aspects of cellular function that would, in turn, affect AP-4 activity. The listed compounds are capable of altering vesicular trafficking, affecting vesicle formation, stabilizing or destabilizing cytoskeletal elements, or disrupting intracellular signaling that would indirectly influence AP-4 functions. The mode of action for each compound interacts with cellular components that are known to either directly or indirectly associate with the functions of the AP-4 complex. The disruption of these components can result in the impairment of AP-4's role in sorting and trafficking proteins to specific destinations within the cell. These chemicals represent a broad spectrum of potential indirect modulators of AP-4, reflecting the complexity of targeting a protein involved in such a fundamental and intricate cellular process as vesicular transport.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent phosphatidylinositol 3-kinase (PI3K) inhibitor. Given that AP-4 is involved in trafficking of proteins and PI3K signaling is crucial for vesicle formation, wortmannin can indirectly affect AP-4 function by disrupting vesicle trafficking pathways. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a dynamin inhibitor, a GTPase involved in the scission of clathrin-coated vesicles. As AP-4 is implicated in the formation of certain vesicles, inhibition of dynamin function can impair the vesicle formation process where AP-4 operates. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Tyrosine kinases are involved in the regulation of various cellular processes, including vesicle trafficking. Inhibiting tyrosine kinases can lead to disruption of pathways where AP-4 might be involved. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of V-ATPases. Since V-ATPases are essential for vesicular acidification, and AP-4 is associated with vesicular transport, inhibition of V-ATPases can alter intravesicular pH and affect AP-4's role in sorting proteins to vesicles. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine is a cationic amphiphilic drug known to affect clathrin-mediated endocytosis. As AP-4 has a role in vesicle formation and trafficking, the alteration in clathrin-mediated processes can affect the function of AP-4. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly. Because microtubules are integral to vesicular transport and AP-4 is involved in vesicle trafficking, paclitaxel can impact AP-4-mediated processes by stabilizing microtubules. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D inhibits actin polymerization. Since actin dynamics are essential for vesicular motility, and AP-4 is involved in vesicle trafficking, disrupting actin filaments can impede AP-4's function in transport processes. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that disrupts ionic gradients across membranes. AP-4’s function in vesicular trafficking can be influenced by ionic changes, which may alter vesicle formation and sorting activities. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML141 is a potent and selective inhibitor of Cdc42, a small GTPase involved in vesicle trafficking. By inhibiting Cdc42, ML141 can affect pathways and processes where AP-4 is required for vesicular transport. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 inhibits clathrin-mediated endocytosis non-competitively. It can affect AP-4's role by altering the formation and trafficking of vesicles that rely on clathrin coats. | ||||||