ANKRD61 Inhibitors
The chemical class of ANKRD61 inhibitors, as listed above, consists of compounds that interfere with various cellular processes and signaling pathways that ANKRD61 may be associated with. These inhibitors work by affecting the activity of enzymes, altering protein stability, and disrupting cellular homeostasis, which can all lead to changes in the function or regulation of ANKRD61. For instance, Wortmannin and LY294002, both PI3K inhibitors, can impact the AKT signaling pathway. This pathway is crucial for a variety of cellular functions, and perturbation of AKT signaling can influence processes where ANKRD61 is a participant. Similarly, PD98059 and SP600125 target the MEK-ERK and JNK pathways, respectively, which are involved in cell proliferation, differentiation, and stress responses. By inhibiting these kinases, the chemicals can alter the cellular context in which ANKRD61 operates.
SB203580, by inhibiting p38 MAP kinase, can modify the inflammatory response, while proteasome inhibitors like MG132 and Bortezomib can affect the degradation of proteins, potentially leading to an indirect increase in ANKRD61 levels or affecting its interactions with other proteins. Z-VAD-FMK, as a broad-spectrum caspase inhibitor, can impact apoptotic pathways, which in turn can alter the cellular environment relevant to ANKRD61. Thapsigargin and Tunicamycin disrupt calcium homeostasis and protein glycosylation, respectively; these disruptions can have wide-ranging effects on the endoplasmic reticulum stress responses and protein folding, potentially influencing ANKRD61's function. Lastly, Cycloheximide and 2-Deoxy-D-glucose, by inhibiting protein synthesis and glycolysis, respectively, can create a cellular environment that affects the stability and regulation of ANKRD61, as well as its associated pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione can inhibit OR6C4 by binding to the odorant binding site, which is necessary for the detection of specific odor molecules. This binding prevents the natural ligands from activating OR6C4, thus inhibiting its function. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper sulfate can interact with OR6C4 leading to the protein’s conformational change which is not conducive to ligand binding. This alteration inhibits the ability of OR6C4 to bind to its odorants, thereby inhibiting its olfactory signaling. | ||||||
Silver nitrate | 7761-88-8 | sc-203378 sc-203378A sc-203378B | 25 g 100 g 500 g | $112.00 $371.00 $1060.00 | 1 | |
Silver nitrate can inhibit OR6C4 through direct interaction with the protein’s binding sites. It can form complexes with amino acids within the binding site, preventing the binding of odorant molecules. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $55.00 $179.00 $345.00 | 1 | |
Cadmium chloride can bind to sulfur-containing ligands on OR6C4, altering the protein's structure and inhibiting its ability to interact with odorant molecules, thereby inhibiting its function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can inhibit OR6C4 by intercalating in the protein structure, thereby changing its conformation and preventing odorant binding, which is crucial for signal transduction in olfactory signaling. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine can inhibit OR6C4 through steric hindrance, where its bulky structure obstructs the odorant binding site. This hinders the ability of odorant molecules to bind to OR6C4, thereby inhibiting the protein's function. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride can inhibit OR6C4 by blocking the ion channels associated with the receptor's signaling pathway. By doing so, it indirectly inhibits the signal transduction normally initiated by OR6C4 activation. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol can inhibit OR6C4 by binding to the receptor pocket, which is critical for interaction with odorant molecules. This binding inhibits the receptor's normal function by blocking signal transduction. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
α-ionone can inhibit OR6C4 by occupying the ligand-binding domain, preventing the natural ligands from activating the receptor. This occupation inhibits the signaling process that OR6C4 typically initiates upon ligand binding. | ||||||