ANKRD26 Inhibitors
ANKRD26 inhibitors are a specialized class of compounds designed to target the ANKRD26 protein, which is part of the ankyrin repeat domain-containing protein family. ANKRD26 is characterized by its ankyrin repeat motifs, structural domains that facilitate protein-protein interactions by creating stable binding surfaces for other proteins. These interactions are crucial for various cellular processes, such as signal transduction, structural organization, and regulation of gene expression. ANKRD26 inhibitors work by interfering with these protein-protein interactions, disrupting the ability of ANKRD26 to participate in the formation and function of multiprotein complexes. By targeting these interactions, inhibitors of ANKRD26 help to modulate specific cellular pathways where the protein plays a key structural or regulatory role.
The chemical structures of ANKRD26 inhibitors vary, encompassing a wide range of small molecules, peptides, and other synthetic constructs designed to interact with the ankyrin repeat domains of the protein. These inhibitors typically function by binding to critical sites within the ankyrin repeats, such as hydrophobic pockets or electrostatic surfaces, thereby blocking the natural binding partners of ANKRD26. In some cases, the inhibitors mimic the structure of natural binding ligands, competing with endogenous proteins for the same binding sites on ANKRD26. Other inhibitors may induce conformational changes that destabilize the ankyrin repeat structure, preventing ANKRD26 from maintaining its functional conformation and disrupting its role in cellular organization. ANKRD26 inhibitors are valuable in research as they provide insights into the functional dynamics of ankyrin repeat proteins and the broader roles they play in regulating cellular systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can cause DNA hypomethylation which may result in the transcriptional silencing of specific genes, including ANKRD26, thereby potentially leading to its downregulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine targets the methylation status of DNA, which could lead to a reduction in ANKRD26 expression by decreasing methyl groups on the gene promoter, making it less transcriptionally active. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid's inhibition of histone deacetylase activity can lead to a less compact chromatin structure, which may result in the decreased expression of genes like ANKRD26 due to changes in histone acetylation patterns. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A increases acetylation of histones, which could decrease expression of ANKRD26 by altering the accessibility of its genomic locus to transcriptional machinery. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin may specifically target the acetylation status of histones associated with the ANKRD26 gene, potentially leading to a reduction in its expression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
By broadly increasing histone acetylation, Panobinostat could lead to a widespread chromatin relaxation, which might include the loci governing ANKRD26, potentially leading to its reduced transcription. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide's selective inhibition of histone deacetylase could result in targeted chromatin remodeling, which may contribute to the specific downregulation of ANKRD26 expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 can lead to the alteration of chromatin structure by increasing histone acetylation, potentially decreasing the expression of the ANKRD26 gene by making its promoter less favorable for transcriptional activation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 disrupts the interaction between acetylated histones and BET bromodomain proteins, which could reduce the initiation of transcription at the ANKRD26 locus, leading to its downregulation. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 may interfere with the recruitment of transcriptional machinery to the promoter of the ANKRD26 gene by inhibiting BET bromodomains, potentially leading to decreased ANKRD26 expression. | ||||||