Angptl6 Inhibitors
Angptl6 inhibitors are a class of chemicals that selectively interact with angiopoietin-like 6 (Angptl6), a protein that is part of the angiopoietin-like family. Angptl6 is known to play a significant role in various biological processes, including angiogenesis, the formation of blood vessels from pre-existing vasculature, and the regulation of energy metabolism. The protein has been found to exert its effects through interactions with specific receptors on the surface of cells, influencing the signaling pathways that contribute to cellular proliferation, differentiation, and survival. Inhibitors targeting Angptl6, therefore, are designed to modulate the biological activity of this protein by binding to it directly or by interfering with its receptor interactions. By doing so, these inhibitors can affect the downstream signaling cascades initiated by Angptl6.
The development of Angptl6 inhibitors involves comprehensive research into the protein's structure and function. To identify potential inhibitors, scientists use a variety of computational and experimental techniques to understand the three-dimensional conformation of Angptl6 and to pinpoint domains that are critical for its activity. High-throughput screening of compound libraries can reveal small molecules that exhibit affinity for Angptl6, and subsequent structure-activity relationship (SAR) studies can refine these hits into more potent and selective inhibitors. The specificity of the interaction between Angptl6 and its inhibitors is crucial, as nonspecific binding could disrupt other angiopoietin-like proteins with similar structures or functions, leading to unintended consequences within the complex network of cellular signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin can inhibit the mTOR pathway, which is involved in cell growth, proliferation, and survival. Angptl6 has been implicated in similar cellular processes, and mTOR inhibition can therefore alter the cellular context in which Angptl6 functions. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K signaling is upstream of several pathways including Akt/mTOR pathway, which can interact with pathways regulated by Angptl6. Inhibiting PI3K can disrupt these pathways and, by extension, Angptl6's role within them. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. This pathway can influence angiogenesis and cellular proliferation, processes in which Angptl6 is involved. Inhibiting MEK can attenuate the pathway's activity, affecting Angptl6-associated functions. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK pathway. The JNK signaling is involved in stress responses and apoptosis, and its inhibition can alter the cellular environment and indirectly affect Angptl6 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a protein that responds to stress stimuli. Because Angptl6 is implicated in metabolic regulation and inflammation, inhibiting p38 MAPK can modulate the processes in which Angptl6 is involved. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor with a broader range than LY294002. By inhibiting PI3K, it can affect the AKT/mTOR pathway, thus influencing cellular processes that Angptl6 may regulate. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. Although not a direct inhibitor, it can influence metabolic pathways that converge or overlap with those regulated by Angptl6, thereby indirectly affecting its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, affecting the ERK pathway. Since Angptl6 is involved in cellular proliferation and angiogenesis, U0126 can modulate these processes by inhibiting the ERK pathway. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine is an AKT inhibitor. By inhibiting AKT, it affects downstream signaling that can intersect with the biological processes where Angptl6 is active. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a potent inhibitor of protein kinase C (PKC). PKC is involved in various cellular processes, including those related to Angptl6's functions. Inhibiting PKC can alter Angptl6-mediated signaling. | ||||||