Date published: 2025-10-18

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Amine-Reactive

Santa Cruz Biotechnology now offers a broad range of Amine-reactive compounds for use in various applications. Amine-reactive compounds are fundamental tools in scientific research, particularly in the fields of biochemistry and molecular biology. These chemicals are designed to selectively react with amine groups, which are prevalent in amino acids and proteins, enabling targeted modifications that are crucial for studying protein structure, function, and interactions. Amine-reactive compounds are extensively utilized in labeling or crosslinking studies, where they facilitate the attachment of fluorescent tags or other markers to proteins for visualization and identification purposes. This makes them invaluable in proteomics, where understanding protein interactions, localization, and dynamics within cells is essential. Additionally, these compounds play a pivotal role in material science for surface modification of polymers and creation of biocompatible materials. In analytical chemistry, amine-reactive dyes and probes are critical for developing assays that can detect and quantify biological molecules, significantly impacting diagnostics and biochemical research. Beyond practical applications, the study of amine-reactive chemistry helps elucidate reaction mechanisms and improve synthetic methodologies, furthering the chemical sciences. The breadth of applications across multiple disciplines underscores the versatility and importance of amine-reactive compounds in advancing scientific knowledge and technology. View detailed information on our available Amine-reactive compounds by clicking on the product name.

Items 1 to 10 of 66 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

CruzFluor™ 647 succinimidyl ester

sc-362620
1 mg
$240.00
3
(1)

CruzFluor™ 647 succinimidyl ester is a highly reactive amine derivative, known for its exceptional ability to form stable amide bonds through nucleophilic attack. Its unique structure enhances the electrophilicity of the ester, facilitating rapid conjugation with primary and secondary amines. The compound's distinct fluorescence properties enable precise tracking in complex biological systems, while its hydrophilic nature ensures compatibility with various aqueous environments, promoting efficient labeling.

CruzFluor™ 488 succinimidyl ester

sc-362617
sc-362617A
1 mg
5 mg
$357.00
$903.00
1
(2)

CruzFluor™ 488 succinimidyl ester is a versatile amine-reactive compound characterized by its strong electrophilic nature, which allows for efficient conjugation with amines. The presence of the succinimidyl group enhances its reactivity, promoting rapid formation of stable amide linkages. Its distinct fluorescence characteristics provide high sensitivity in detection applications, while its solubility in polar solvents supports diverse experimental conditions, ensuring reliable performance in various assays.

CFSE

150347-59-4sc-202096
25 mg
$210.00
12
(1)

CFSE is a highly reactive amine derivative known for its unique ability to form stable covalent bonds with amines through nucleophilic attack. This compound exhibits a distinctive mechanism of action, facilitating rapid reaction kinetics that enable efficient labeling and tracking of biomolecules. Its hydrophilic nature enhances solubility in aqueous environments, promoting effective interaction with target amines. Additionally, CFSE's structural features contribute to its stability under various conditions, making it a reliable choice for diverse applications.

Tetramethylrhodamine isothiocyanate mixed isomers

95197-95-8sc-215958
5 mg
$95.00
(1)

Tetramethylrhodamine isothiocyanate mixed isomers are characterized by their vibrant fluorescence and reactivity towards amines, enabling the formation of thiourea linkages. This compound exhibits a unique propensity for selective labeling, driven by its electrophilic isothiocyanate group, which engages in rapid nucleophilic substitution reactions. Its robust photostability and high quantum yield make it particularly effective in various environments, enhancing its utility in molecular studies.

5-Carboxyfluorescein-N-hydroxysuccinimide Ester

92557-80-7sc-210302
25 mg
$456.00
(0)

5-Carboxyfluorescein-N-hydroxysuccinimide Ester is a highly reactive fluorescent dye that interacts specifically with amines through its N-hydroxysuccinimide (NHS) moiety. This compound facilitates the formation of stable amide bonds, showcasing a rapid reaction kinetics that is advantageous for bioconjugation processes. Its distinct spectral properties, including strong absorbance and emission characteristics, allow for effective tracking in complex biological systems, making it a versatile tool for studying molecular interactions.

CruzFluor™ 555 succinimidyl ester

sc-362618
sc-362618A
sc-362618B
1 mg
5 mg
10 mg
$234.00
$650.00
$1300.00
(1)

CruzFluor™ 555 succinimidyl ester is a potent fluorescent labeling agent that exhibits remarkable reactivity with amine groups, driven by its succinimidyl ester functionality. This compound undergoes efficient nucleophilic attack, leading to the formation of stable conjugates. Its unique photophysical properties, including high quantum yield and distinct emission spectra, enable precise visualization in diverse experimental contexts, enhancing the study of biomolecular interactions and dynamics.

CruzFluor™ 405 succinimidyl ester

sc-362616
sc-362616A
1 mg
5 mg
$403.00
$974.00
(2)

CruzFluor™ 405 succinimidyl ester is a highly reactive compound that selectively targets amine groups through its succinimidyl ester moiety. This reactivity facilitates rapid conjugation, resulting in stable adducts that exhibit enhanced fluorescence. The compound's unique spectral properties, including a distinct excitation wavelength, allow for effective multiplexing in imaging applications. Its efficient reaction kinetics make it an ideal choice for studying complex molecular interactions in real-time.

Fluorescein isothiocyanate isomer I

3326-32-7sc-206015
sc-206015A
sc-206015B
sc-206015C
250 mg
1 g
5 g
25 g
$104.00
$198.00
$785.00
$2866.00
1
(1)

Fluorescein isothiocyanate isomer I is a potent electrophile that engages amine groups through its isothiocyanate functionality, leading to the formation of thiourea linkages. This reaction is characterized by its high specificity and rapid kinetics, enabling efficient labeling of biomolecules. The compound exhibits strong fluorescence, with a unique emission profile that enhances visibility in various assays. Its stability in aqueous environments further supports diverse experimental conditions, making it a versatile tool for probing molecular dynamics.

3-Bodipy-propanoic Acid

165599-63-3sc-216412
5 mg
$275.00
(1)

3-Bodipy-propanoic Acid is a highly reactive compound that interacts with amines through its carboxylic acid group, facilitating the formation of stable amide bonds. This reaction is notable for its selectivity and moderate reaction rates, allowing for controlled modifications in complex mixtures. The compound's unique optical properties, including strong absorption and fluorescence, make it an excellent candidate for studying molecular interactions and dynamics in various environments. Its solubility in polar solvents enhances its applicability in diverse chemical contexts.

1-Pyrenebutyric acid N-hydroxysuccinimide ester

114932-60-4sc-213409
sc-213409A
sc-213409B
sc-213409C
1 g
5 g
10 g
100 g
$276.00
$1170.00
$2295.00
$13770.00
4
(0)

1-Pyrenebutyric acid N-hydroxysuccinimide ester exhibits remarkable reactivity towards amines, primarily through its N-hydroxysuccinimide moiety, which promotes efficient amide bond formation. This compound showcases a unique ability to facilitate selective coupling reactions, characterized by rapid kinetics and minimal side reactions. Its distinct photophysical properties, including strong fluorescence, enable real-time monitoring of reaction progress, making it a valuable tool for probing molecular interactions in various settings.