ALS2CL Activators
ALS2CL is a gene that has garnered attention in the scientific community due to its role in cellular processes. The protein encoded by ALS2CL is thought to be involved in various intracellular signaling pathways, although the full scope of its functions remains an area of active research. Understanding how to upregulate the expression of ALS2CL is of particular interest because of its potential involvement in key cellular mechanisms. The regulation of gene expression is a complex interaction between various biochemical factors, including chemical compounds that can act as activators to induce gene expression. These activators can bind to specific sites on DNA or interact with the cellular machinery to stimulate the production of the ALS2CL protein.
Several chemicals have been identified as potential inducers of ALS2CL expression. For instance, Retinoic Acid, a metabolite of vitamin A, is known for its role in gene transcription related to cellular differentiation and could potentially upregulate ALS2CL. Similarly, Forskolin, a plant-derived compound, has been shown to increase the cellular levels of cAMP, which can lead to the activation of transcription factors that stimulate ALS2CL expression. Histone deacetylase inhibitors like Trichostatin A and Sodium Butyrate are also of interest; they work by modifying the chromatin structure, making it easier for transcription factors to access the DNA and initiate the transcription of ALS2CL. Moreover, compounds like 5-Azacytidine and Lithium Chloride are thought to promote ALS2CL expression by inhibiting enzymes that would otherwise suppress gene expression, such as DNA methyltransferases and GSK-3, respectively. Other potential activators include natural compounds like Curcumin and Sulforaphane, which are believed to activate cellular defense pathways that could include the transcription of ALS2CL. The study of these activators, and their interactions with cellular pathways, continues to be a vibrant field of research, with ongoing efforts to elucidate the precise mechanisms by which they can stimulate ALS2CL expression.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could upregulate ALS2CL by binding to its nuclear receptors, leading to the activation of gene transcription programs associated with neural differentiation and plasticity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin may stimulate ALS2CL expression by elevating intracellular cAMP levels, which in turn could activate protein kinase A (PKA) and subsequent phosphorylation of transcription factors that drive gene expression in neural cells. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase activity, Trichostatin A could result in a relaxed chromatin structure at the ALS2CL promoter region, facilitating transcriptional machinery access and leading to increased ALS2CL gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine could promote ALS2CL transcription by incorporating into DNA and RNA, subsequently inhibiting DNA methyltransferase, which often silences gene expression, thus potentially reversing the silencing of ALS2CL. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate may enhance the transcription of ALS2CL by providing an acetylated state of histones, which is associated with active transcription, promoting a more open chromatin structure around the ALS2CL gene. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride could stimulate ALS2CL gene expression through the inhibition of GSK-3, which may enhance the activity of transcription factors such as Wnt/β-catenin that have roles in neuronal gene expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone could induce ALS2CL expression by activating glucocorticoid receptors, leading to the binding of receptor complexes to glucocorticoid response elements within the promoter region of ALS2CL. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide may upregulate ALS2CL as part of an adaptive cellular response to oxidative stress by activating redox-sensitive transcription factors that target genes involved in cytoprotection. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may stimulate ALS2CL gene expression through its ability to activate transcription factors like NF-κB and AP-1, which are involved in the cellular response to inflammation and oxidative stress. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could potentially induce ALS2CL expression by activating the NRF2 signaling pathway, which is known to upregulate genes associated with antioxidant defense mechanisms. | ||||||