SEE ALSO...
Items 11 to 17 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Indirect activator that can activate α2A-AR, modulating receptor-mediated signaling pathways in response to stress or excitement. | ||||||
Guanfacine | 29110-47-2 | sc-353618 | 200 mg | $1900.00 | ||
Guanfacine selectively targets the alpha2A-adrenergic receptor, demonstrating a unique affinity that enhances receptor conformational stability. Its binding involves intricate electrostatic interactions and van der Waals forces, facilitating a nuanced modulation of neurotransmitter release. The compound influences downstream signaling cascades, particularly affecting calcium ion dynamics and neurotransmitter vesicle fusion. Its structural characteristics contribute to a favorable distribution in lipid environments, impacting its interaction with cellular membranes. | ||||||
Clonidine | 4205-90-7 | sc-501519 | 100 mg | $235.00 | 1 | |
Direct activator of α2A-AR by binding to the receptor, leading to its activation and subsequent modulation of downstream signaling pathways. | ||||||
p-Iodoclonidine hydrochloride | 108294-53-7 | sc-257955 | 25 mg | $45.00 | ||
p-Iodoclonidine hydrochloride exhibits a distinctive interaction profile with the alpha2A-adrenergic receptor, characterized by its halogen substitution that enhances receptor affinity and specificity. This compound engages in hydrogen bonding and hydrophobic interactions, promoting a unique conformational change in the receptor. Its presence influences intracellular signaling pathways, particularly those involving cyclic AMP modulation, thereby affecting neuronal excitability and synaptic transmission. The compound's lipophilicity aids in its membrane permeability, facilitating rapid cellular uptake and interaction with lipid bilayers. | ||||||
Salmeterol | 89365-50-4 | sc-224277 sc-224277A | 10 mg 50 mg | $186.00 $562.00 | 1 | |
Indirect activator that can stimulate α2A-AR via β2-adrenergic receptor activation, leading to crosstalk between receptor pathways. | ||||||
Reserpine | 50-55-5 | sc-203370 sc-203370A | 1 g 5 g | $134.00 $406.00 | 1 | |
Indirect activator that depletes norepinephrine stores, indirectly enhancing α2A-AR activation by reducing endogenous ligand levels. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Indirect activator that stimulates α2A-AR through β1-adrenergic receptor activation, promoting cardiac effects and receptor crosstalk. | ||||||