Date published: 2025-12-15

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alpha2A-AR Activators

Santa Cruz Biotechnology now offers a broad range of alpha2A-AR Activators for use in various applications. Alpha2A-AR Activators are essential tools in scientific research, particularly for studying the function and signaling mechanisms of the alpha-2A adrenergic receptor (AR), a subtype of G protein-coupled receptors that plays a pivotal role in modulating neurotransmitter release, vascular tone, and central nervous system activities. The alpha2A-AR is widely expressed in the brain, heart, and blood vessels, where it regulates various physiological processes such as blood pressure, sedation, and inhibition of norepinephrine release. By using specific activators, researchers can selectively stimulate these receptors to investigate their role in modulating synaptic transmission, vascular resistance, and stress responses. These activators are particularly valuable in research focused on understanding the complex signaling pathways that are triggered by alpha2A-AR activation and how these pathways influence both normal physiological functions and potential pathological states. In the scientific community, alpha2A-AR Activators are widely utilized in studies exploring receptor biology, neurotransmitter dynamics, and the effects of receptor activation on cardiovascular and central nervous system function. Researchers often employ these activators in various experimental models, including in vitro assays and in vivo animal studies, to gain insights into the receptor's role in maintaining homeostasis and its potential as a target for modulating physiological responses. The availability of high-quality alpha2A-AR Activators is crucial for advancing research in fields such as neuroscience, and cardiovascular biology, providing the necessary tools to explore the intricate roles of alpha2A-AR in health and disease. View detailed information on our available alpha2A-AR Activators by clicking on the product name.

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Items 11 to 17 of 17 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

(−)-Epinephrine

51-43-4sc-205674
sc-205674A
sc-205674B
sc-205674C
sc-205674D
1 g
5 g
10 g
100 g
1 kg
$40.00
$102.00
$197.00
$1739.00
$16325.00
(1)

Indirect activator that can activate α2A-AR, modulating receptor-mediated signaling pathways in response to stress or excitement.

Guanfacine

29110-47-2sc-353618
200 mg
$1900.00
(0)

Guanfacine selectively targets the alpha2A-adrenergic receptor, demonstrating a unique affinity that enhances receptor conformational stability. Its binding involves intricate electrostatic interactions and van der Waals forces, facilitating a nuanced modulation of neurotransmitter release. The compound influences downstream signaling cascades, particularly affecting calcium ion dynamics and neurotransmitter vesicle fusion. Its structural characteristics contribute to a favorable distribution in lipid environments, impacting its interaction with cellular membranes.

Clonidine

4205-90-7sc-501519
100 mg
$235.00
1
(0)

Direct activator of α2A-AR by binding to the receptor, leading to its activation and subsequent modulation of downstream signaling pathways.

p-Iodoclonidine hydrochloride

108294-53-7sc-257955
25 mg
$45.00
(1)

p-Iodoclonidine hydrochloride exhibits a distinctive interaction profile with the alpha2A-adrenergic receptor, characterized by its halogen substitution that enhances receptor affinity and specificity. This compound engages in hydrogen bonding and hydrophobic interactions, promoting a unique conformational change in the receptor. Its presence influences intracellular signaling pathways, particularly those involving cyclic AMP modulation, thereby affecting neuronal excitability and synaptic transmission. The compound's lipophilicity aids in its membrane permeability, facilitating rapid cellular uptake and interaction with lipid bilayers.

Salmeterol

89365-50-4sc-224277
sc-224277A
10 mg
50 mg
$186.00
$562.00
1
(1)

Indirect activator that can stimulate α2A-AR via β2-adrenergic receptor activation, leading to crosstalk between receptor pathways.

Reserpine

50-55-5sc-203370
sc-203370A
1 g
5 g
$134.00
$406.00
1
(2)

Indirect activator that depletes norepinephrine stores, indirectly enhancing α2A-AR activation by reducing endogenous ligand levels.

Dobutamine

34368-04-2sc-507555
100 mg
$295.00
(0)

Indirect activator that stimulates α2A-AR through β1-adrenergic receptor activation, promoting cardiac effects and receptor crosstalk.