α E-catenin Inhibitors
α E-catenin inhibitors are a class of chemical compounds that specifically target and interact with α E-catenin, a protein found in cells that plays a pivotal role in cell-cell adhesion and signaling pathways. α E-catenin is part of the cadherin-catenin complex, which is essential for maintaining the integrity of epithelial tissues and orchestrating various cellular processes, including cell migration, proliferation, and differentiation. These inhibitors are designed to modulate the activity of α E-catenin, either by binding to it directly or by interfering with its interactions with other proteins, ultimately leading to alterations in cellular behavior.
The precise mechanisms through which α E-catenin inhibitors exert their effects can vary, but they generally aim to disrupt the interactions between α E-catenin and other proteins, such as β-catenin and vinculin. By doing so, they can influence the stability of adherens junctions, which are critical for maintaining tissue integrity. Additionally, these inhibitors can affect the Wnt signaling pathway, as α E-catenin is known to interact with β-catenin, a key component of this pathway. Consequently, α E-catenin inhibitors have garnered significant attention in the field of cell biology and research, as they provide valuable tools for studying cell adhesion, migration, and signaling. Understanding their mechanisms of action and their impact on cellular processes is crucial for unraveling the intricate biology of α E-catenin and its associated pathways, leading to insights into various physiological and pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This compound is a DNA methyltransferase inhibitor, which can lead to demethylation of genes and potentially affect their expression, including α E-catenin. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it modifies chromatin structure and can influence gene expression, potentially altering α E-catenin levels. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
An inhibitor of PI3K, it affects various cellular processes, including cell survival and proliferation, which could indirectly influence α E-catenin expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Through its action on the mTOR pathway, rapamycin affects protein synthesis and cell growth, potentially impacting α E-catenin expression. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
As a kinase inhibitor, it affects cell signaling pathways, which could result in changes in α E-catenin expression. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Targeting the EGFR pathway, gefitinib can alter cell signaling and potentially influence α E-catenin levels. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor, staurosporine can affect various signaling pathways, potentially impacting α E-catenin expression. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
This compound inhibits the Hedgehog signaling pathway, which could result in changes in cell differentiation and potentially α E-catenin levels. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
As a histone deacetylase inhibitor, it can alter chromatin structure and potentially influence α E-catenin expression. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
By inhibiting ROCK, this compound affects cell shape and motility, which could potentially influence α E-catenin levels. | ||||||