ALDH1L2 Activators
ALDH1L2 Activators, belonging to the class of small molecules, are chemical compounds specifically designed to modulate the activity of the enzyme aldehyde dehydrogenase 1 family member L2 (ALDH1L2). ALDH1L2 is a crucial enzyme in the cellular metabolism of folate, which plays an essential role in one-carbon metabolism, a fundamental biochemical pathway involved in the synthesis of nucleotides, amino acids, and other important cellular components. These activators are designed to interact with ALDH1L2 and enhance its enzymatic activity, thereby influencing the flux of folate-related intermediates within cells.
The rationale behind developing ALDH1L2 activators lies in the pivotal role of ALDH1L2 in regulating folate metabolism. By modulating the activity of this enzyme, these compounds can impact various cellular processes, including DNA synthesis, repair, and methylation, as well as amino acid metabolism. The precise mechanisms by which ALDH1L2 activators achieve their effects can vary, but they generally involve increasing the efficiency of ALDH1L2 in converting 10-formyltetrahydrofolate to tetrahydrofolate, a key step in folate metabolism. This enhanced enzymatic activity may lead to alterations in the availability of one-carbon units and thus impact the overall balance of cellular processes dependent on these units. Consequently, these compounds hold promise for research and applications in fields such as cellular metabolism studies and investigations into the role of folate in health and disease. Research in this area continues to explore the precise mechanisms and implications of ALDH1L2 activation, shedding light on its relevance in various biological contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor in redox reactions. It may activate ALDH1L2 by participating in the enzyme's catalytic mechanism, facilitating the conversion of aldehydes to their corresponding carboxylic acids. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP can serve as an energy source for various cellular processes, including those involved in enzyme activation and function. It may indirectly influence ALDH1L2 by providing the necessary energy for its activity. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
CoA plays a crucial role in fatty acid metabolism. While not directly involved in ALDH1L2 activation, it may indirectly influence the enzyme's activity by affecting the availability of substrates and intermediates in metabolic pathways that interact with ALDH1L2. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Lipoic acid is a cofactor in some enzymes involved in redox reactions. It may activate ALDH1L2 by facilitating electron transfer reactions or by modulating the enzyme's structure or function. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
NR is a precursor to NAD+, a cofactor involved in redox reactions. It may indirectly activate ALDH1L2 by supporting NAD+ levels, which are necessary for the enzyme's function. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
Like NR, NMN is a precursor to NAD+. It may activate ALDH1L2 by increasing cellular NAD+ levels, which can enhance the enzyme's catalytic activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM is involved in methylation reactions. While not directly linked to ALDH1L2 activation, it may indirectly influence the enzyme's function by participating in methylation events that regulate its activity or expression. | ||||||
Tetrahydrofolic acid | sc-215955 sc-215955A sc-215955B | 25 mg 100 mg 1 g | $105.00 $285.00 $1005.00 | |||
THF is a cofactor in one-carbon metabolism, which is interconnected with various metabolic pathways, including those related to aldehyde metabolism. It may affect ALDH1L2 indirectly by regulating one-carbon metabolism. | ||||||
Thiamine pyrophosphate | 154-87-0 | sc-215966 sc-215966A sc-215966B sc-215966C sc-215966D | 1 g 5 g 25 g 100 g 1 kg | $33.00 $97.00 $290.00 $1149.00 $6024.00 | 1 | |
TPP is a cofactor in enzymes involved in carbohydrate metabolism. While not directly involved in ALDH1L2 activation, it may impact the enzyme's activity by influencing metabolic pathways that intersect with ALDH1L2-related processes. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
PLP is a cofactor in enzymes involved in amino acid metabolism. Its availability may indirectly affect ALDH1L2 activation by modulating amino acid-related pathways that interact with the enzyme. | ||||||