AKR7 Inhibitors
Chemical inhibitors of AKR7 can interfere with the protein's function through various mechanisms. Acrolein, for example, can form adducts with cysteine residues in the active site of AKR7, perturbing the catalytic mechanism that is central to the protein's detoxification function. Similarly, cinnamaldehyde can bind to nucleophilic amino acid residues, leading to inhibition through steric hindrance and modification of the active site conformation. Ethacrynic acid, known for its ability to inhibit glutathione S-transferases, can also inhibit AKR7 by covalently modifying key cysteine residues, obstructing the catalytic reduction of substrates. Phloretin acts as a competitive inhibitor by binding to the substrate binding sites of AKR7, thereby blocking substrate access and inhibiting the enzyme's function. Sulforaphane targets AKR7 by altering thiol groups within the active site, modifying the enzyme's structure and inhibiting its activity.
Continuing with the variety of mechanisms by which chemicals can inhibit AKR7, hesperidin can bind to allosteric sites on the protein, inducing conformational changes that reduce substrate affinity, which leads to inhibition. Menadione indirectly inhibits AKR7 via redox cycling, generating reactive oxygen species that oxidize important thiol groups, leading to the loss of enzymatic activity. Curcumin inhibits AKR7 by interfering with the active site and disrupting substrate interaction. Capsaicin can alter the conformation of AKR7 or interact with key residues necessary for activity, leading to inhibition. Nordihydroguaiaretic acid inhibits AKR7 either by competing with natural substrates at the active site or by modifying essential residues. Oleanolic acid can insert into the substrate binding site, blocking the processing of natural substrates and inhibiting the enzyme. Lastly, quercetin, a known flavonoid, can inhibit AKR7 by competing with coenzyme and substrate binding sites, effectively reducing the activity of the enzyme.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $102.00 $224.00 | ||
Cinnamaldehyde can form covalent bonds with nucleophilic amino acid residues in AKR7, leading to the inhibition of its catalytic activity by steric hindrance and potential alteration of the active site conformation. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $49.00 $229.00 | 5 | |
Ethacrynic acid is known to inhibit glutathione S-transferases by covalently modifying cysteine residues. It can similarly inhibit AKR7 by binding and modifying essential cysteine residues, thereby preventing the catalytic reduction of substrates. | ||||||
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin can inhibit AKR7 by interfering with the enzyme's substrate binding sites. As a competitive inhibitor, it can bind to the active site of AKR7, blocking access for the natural substrates and thus inhibiting the enzyme's function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can inhibit AKR7 by interacting with thiol groups in the active site, modifying the enzyme's structure and function, thus leading to the inhibition of its activity. | ||||||
Hesperidin | 520-26-3 | sc-205711 sc-205711A | 25 g 100 g | $80.00 $200.00 | 5 | |
Hesperidin can inhibit AKR7 by binding to its allosteric sites, inducing a conformational change that reduces the enzyme's affinity for its substrates, thereby inhibiting its activity. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
Menadione can inhibit AKR7 indirectly by undergoing redox cycling and generating reactive oxygen species (ROS), which can oxidize essential thiol groups in the enzyme, leading to loss of activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit AKR7 by binding to the enzyme's active site, interfering with substrate interaction, and possibly inducing a conformational change that disrupts catalytic activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin can inhibit AKR7 by binding to the enzyme and altering its conformation or by interacting with key amino acid residues required for enzymatic activity, thus leading to functional inhibition. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
Nordihydroguaiaretic acid can inhibit AKR7 by binding to the active site and competing with the natural substrates, or by modifying essential residues required for enzymatic activity, leading to inhibition. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
Oleanolic acid can inhibit AKR7 by inserting itself into the substrate binding site, preventing the approach and processing of natural substrates, thus inhibiting the enzyme's function. | ||||||