AKAP 150 Inhibitors
Chemical inhibitors of AKAP 150 encompass a diverse group of compounds that modulate the function of this scaffolding protein indirectly by targeting the kinases it interacts with or influences. AKAP 150's primary role is to target PKA to specific subcellular locations, hence compounds that inhibit PKA, such as H-89 and KT 5720, disrupt AKAP 150's ability to form signaling complexes that are crucial for the propagation of PKA-mediated signaling. The specificity and efficacy of these compounds in inhibiting PKA directly affect AKAP 150's scaffolding function, thereby modulating the downstream signaling events it regulates. In addition to PKA, AKAP 150 is also known to bind to other kinases like PKC and CaMKII, which play roles in a wide array of cellular processes including calcium signaling and cytoskeletal reorganization. Compounds like Gö 6983 and Chelerythrine specifically inhibit PKC, which may affect AKAP 150-mediated signaling by altering its phosphorylation state and modulating its interaction with other signaling molecules. Similarly, CaMKII inhibitors such as KN-93 and the autocamtide-2-related inhibitory peptide can impact AKAP 150's role in calcium-dependent signaling pathways.
The diversity in the chemical structure and target specificity of these compounds illustrates the complex regulatory mechanisms that AKAP 150 is involved in. The modulation of these interactions and signaling cascades by such inhibitors indicates that AKAP 150's activity can be influenced by the precise control of kinase activities within the cell. Consequently, these compounds serve as tools to elucidate the biological functions of AKAP 150 and the importance of spatial and temporal organization of signaling molecules in cellular communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII phosphorylation affects AKAP150 anchoring. KN-93 disrupts CaMKII activity, potentially altering the association of AKAP150 with its target proteins, indirectly leading to its functional inhibition. | ||||||
Rp-8-Br-cAMPS | 129735-00-8 | sc-3539A sc-3539 | 500 µg 1 mg | $194.00 $336.00 | 22 | |
Rp-8-Br-cAMPS is a PKA inhibitor that competes with cAMP. AKAP150 anchors PKA to specific cellular locations. By inhibiting PKA activity, this compound could indirectly modulate the signaling cascades facilitated by AKAP150 scaffolding. | ||||||
PKI (14-22) amide (myristoylated) | 201422-03-9 | sc-471154 | 0.5 mg | $132.00 | 2 | |
This compound is a potent and specific inhibitor of PKA. By disrupting PKA activity, it can indirectly affect AKAP150's role in directing PKA to specific targets, potentially modulating the pathways AKAP150 regulates. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $126.00 $210.00 $488.00 | 19 | |
K252a is a kinase inhibitor with broad specificity, including PKA. By inhibiting PKA, K252a can disrupt AKAP150-PKA interactions and therefore modulate AKAP150-mediated signaling events. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $97.00 $144.00 $648.00 | 47 | |
KT 5720 is a PKA inhibitor. By preventing PKA activity, it can indirectly disrupt the AKAP150-dependent localization of PKA and thereby modulate the signaling pathways involving AKAP150. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a broad-spectrum protein kinase C (PKC) inhibitor. As PKC can phosphorylate AKAP150, inhibiting PKC activity could result in altered AKAP150-mediated signaling pathways. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a selective inhibitor of PKC. Inhibition of PKC activity may decrease the phosphorylation of AKAP150 and its associated proteins, leading to an indirect modulation of AKAP150's functions. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
Ro 31-8220 is a potent PKC inhibitor that can also inhibit other kinases. By targeting PKC, it could alter the phosphorylation status of AKAP150 and its ability to scaffold signaling complexes. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of many protein kinases, including PKA. It can non-selectively disrupt kinase interactions with AKAP150, thereby indirectly affecting its signaling functions. | ||||||