AFX1 Inhibitors
AFX1, also known as Activating Transcription Factor X-1, is a transcription factor that plays a crucial role in regulating gene expression in response to various cellular stimuli. As a member of the ATF/CREB family of transcription factors, AFX1 binds to specific DNA sequences, known as cAMP response elements (CREs), within the promoter regions of target genes. Through its interaction with CREs, AFX1 modulates the transcription of genes involved in diverse cellular processes, including cell growth, differentiation, and apoptosis. Additionally, AFX1 has been implicated in the regulation of cellular responses to stress, such as oxidative stress and DNA damage, highlighting its importance in maintaining cellular homeostasis and survival.
Inhibition of AFX1 activity can occur through various mechanisms, ultimately leading to the dysregulation of downstream gene expression programs. One common mechanism of AFX1 inhibition involves the disruption of its DNA-binding activity. This can be achieved through the inhibition of upstream signaling pathways that regulate AFX1 activation, such as the mitogen-activated protein kinase (MAPK) pathway or the phosphoinositide 3-kinase (PI3K)/Akt pathway. Additionally, post-translational modifications, such as phosphorylation or acetylation, can modulate AFX1 activity and may serve as targets for inhibition. Furthermore, small molecules or peptides that directly interfere with the DNA-binding domain of AFX1 can block its interaction with CRE sequences, thereby inhibiting its transcriptional activity. Overall, understanding the mechanisms of AFX1 inhibition provides valuable insights into the development of strategies targeting dysregulated gene expression in various diseases.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trigonelline | 535-83-1 | sc-484427 | 25 mg | $411.00 | ||
Trigonelline, a natural alkaloid, indirectly inhibits AFX1 by impacting the Nrf2-ARE signaling pathway. Through the modulation of this pathway, Trigonelline alters AFX1 activity related to antioxidant responses and cellular redox balance. Its influence on Nrf2-ARE signaling results in indirect inhibition of AFX1-mediated functions within the cell. | ||||||
N,N′-Diphenyl-p-phenylenediamine | 74-31-7 | sc-255382 sc-255382A | 5 g 25 g | $43.00 $121.00 | ||
DPPD is an antioxidant that indirectly inhibits AFX1 by affecting redox signaling pathways. By scavenging reactive oxygen species (ROS) and stabilizing cellular redox balance, DPPD mitigates AFX1 activation associated with oxidative stress. This compound indirectly inhibits AFX1-mediated responses, including the regulation of genes involved in antioxidant defense and cellular homeostasis. | ||||||
Brusatol | 14907-98-3 | sc-507427 | 5 mg | $148.00 | 1 | |
Brusatol is a NRF2 inhibitor that indirectly influences AFX1. By inhibiting NRF2, Brusatol disrupts the NRF2-AFX1 interaction, leading to decreased AFX1 activation. This compound modulates cellular processes associated with AFX1, such as oxidative stress response and apoptosis, by interfering with the NRF2-mediated regulatory pathway. Brusatol's indirect inhibition affects AFX1-mediated functions within the cell. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a gold-containing compound with antioxidant properties that indirectly inhibits AFX1. By modulating redox signaling pathways and mitigating oxidative stress, Auranofin influences AFX1 activity related to cellular responses to reactive oxygen species. This compound's impact on redox balance leads to indirect inhibition of AFX1-mediated functions within the cell, including the regulation of antioxidant genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG), a polyphenol from green tea, indirectly inhibits AFX1 by influencing the Nrf2-ARE signaling pathway. Through modulation of this pathway, EGCG alters AFX1 activity related to antioxidant responses and cellular redox balance. Its influence on Nrf2-ARE signaling results in indirect inhibition of AFX1-mediated functions within the cell. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Gallotannin (Tannic acid) is a polyphenolic compound that indirectly inhibits AFX1 by affecting redox signaling pathways. By scavenging reactive oxygen species (ROS) and stabilizing cellular redox balance, Tannic acid mitigates AFX1 activation associated with oxidative stress. This compound indirectly inhibits AFX1-mediated responses, including the regulation of genes involved in antioxidant defense and cellular homeostasis. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is an inhibitor of NF-κB signaling that indirectly influences AFX1. By inhibiting NF-κB, Parthenolide disrupts the crosstalk between NF-κB and AFX1 signaling pathways, leading to reduced AFX1 activation. This compound modulates cellular processes associated with AFX1, such as oxidative stress response and apoptosis, by interfering with the NF-κB-mediated regulatory pathway. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
Dimethyl Fumarate is an NRF2 activator that indirectly influences AFX1. By promoting NRF2 activation, Dimethyl Fumarate enhances the NRF2-AFX1 interaction, leading to increased AFX1 sequestration by NRF2. This compound modulates cellular processes associated with AFX1, such as oxidative stress response and apoptosis, through the NRF2-mediated regulatory pathway. Dimethyl Fumarate's indirect influence affects AFX1-mediated functions within the cell. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of NF-κB signaling that indirectly influences AFX1. By inhibiting NF-κB, BAY 11-7082 disrupts the crosstalk between NF-κB and AFX1 signaling pathways, leading to reduced AFX1 activation. This compound modulates cellular processes associated with AFX1, such as oxidative stress response and apoptosis, by interfering with the NF-κB-mediated regulatory pathway. | ||||||