Aex-3 Activators
The chemical class of AEX-3 Modulators encompasses a range of compounds that can indirectly influence the activity of the AEX-3 Rab GTPase in C. elegans. These modulators work primarily by affecting cellular trafficking processes, membrane dynamics, and endocytic pathways.
The first subgroup within this class includes compounds like Brefeldin A, Nocodazole, and Wortmannin, which disrupt various aspects of intracellular trafficking. For example, Brefeldin A affects the structure and function of the Golgi apparatus, leading to alterations in vesicle transport that could indirectly impact AEX-3 activity. Nocodazole, by disrupting microtubule dynamics, influences the transport of vesicles, a process in which Rab GTPases like AEX-3 are involved. Another significant subgroup involves inhibitors of specific proteins and processes linked to vesicle trafficking, such as Dynasore, Monensin, and Pitstop 2. These compounds modulate the function of proteins critical for vesicle formation and transport. For instance, Dynasore's inhibition of dynamin, a key protein in vesicle scission.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts Golgi apparatus function and can affect vesicle trafficking pathways, potentially influencing AEX-3 activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, which can impact vesicle transport and potentially AEX-3 function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin affects intracellular ion concentrations and vesicle transport, potentially impacting AEX-3 function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filament formation, which can influence vesicle trafficking and potentially AEX-3 activity. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $33.00 $131.00 | 3 | |
This compound inhibits PIKfyve, affecting endosomal trafficking, which might impact AEX-3 function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a Cdc42 inhibitor, potentially affecting pathways involved in membrane trafficking and AEX-3 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can affect multiple signaling pathways, potentially impacting AEX-3 function. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine can inhibit clathrin-mediated endocytosis, potentially affecting AEX-3 activity. | ||||||