Adh1 Inhibitors
Adh1 inhibitors are a class of compounds that target the enzyme alcohol dehydrogenase 1 (ADH1), which plays a central role in the metabolic oxidation of alcohols to aldehydes. Alcohol dehydrogenases are a group of zinc-containing enzymes that catalyze the conversion of alcohols, such as ethanol, methanol, and other primary and secondary alcohols, into their corresponding aldehyde derivatives. ADH1, specifically, is one of the isoforms of alcohol dehydrogenase predominantly found in the liver and to some extent in other tissues. The inhibition of ADH1 blocks the enzyme's ability to convert alcohols into aldehydes, thus halting the oxidation pathway at the alcohol stage. This can be significant for studying metabolic pathways where alcohols serve as intermediates or final products.
The molecular mechanism of Adh1 inhibition generally involves the binding of inhibitors to the active site of the enzyme, where they can coordinate with the zinc ion present in the catalytic core. This coordination can alter the enzyme's conformation, preventing it from interacting with alcohol substrates. Additionally, some inhibitors may compete directly with the alcohol substrate by binding to the same active site or may interact allosterically, inducing conformational changes that reduce enzyme activity. The study of ADH1 inhibitors is important in biochemistry and enzymology, as they can provide insights into alcohol metabolism, redox biology, and enzymatic regulation. These inhibitors also serve as useful tools in biochemical research to dissect the role of alcohol dehydrogenase in various biological systems and metabolic processes, especially those involving aldehydes and alcohols as key intermediates.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylase activity, leading to hyperacetylation of histones and potentially repressing Adh1 gene transcription through chromatin remodeling. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine can cause DNA demethylation, which may result in the decreased expression of the Adh1 gene due to epigenetic alterations. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors, which may downregulate Adh1 expression through receptor-mediated changes in gene transcription patterns. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and disrupts RNA polymerase action, which can lead to a cessation of Adh1 mRNA synthesis and a subsequent decrease in Adh1 protein levels. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine specifically inhibits the Hedgehog signaling pathway, potentially leading to a downregulation of Adh1 expression if this pathway promotes its expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to mTOR, inhibiting its function, which may lead to reduced protein synthesis and cellular growth, resulting in a decrease in Adh1 expression as part of a wider cellular response to inhibited growth signals. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 inhibits the PI3K/Akt pathway, which could lead to a reduction in Adh1 gene expression by altering transcriptional activity and cellular metabolism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane can induce the production of detoxifying enzymes, potentially leading to a reduction in Adh1 expression by altering the cellular redox state and gene expression profiles. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to inhibit the activation of NF-κB, a transcription factor that could be responsible for the upregulation of Adh1, thus leading to a decrease in its expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been observed to downregulate the expression of genes involved in inflammation and proliferation, which may include a reduction in Adh1 gene expression through alterations in cellular signaling pathways. | ||||||