ADAM26 Activators
ADAM26 Activators comprise a group of diverse chemical compounds that indirectly augment the functional activity of ADAM26 through various signaling pathways, focusing primarily on processes related to cell adhesion, migration, and proteolysis. Resveratrol and Epigallocatechin gallate, by modulating the AMPK and various kinase pathways respectively, enhance ADAM26's functional role in these processes. Forskolin, through the elevation of cAMP levels, and LY294002, a PI3K inhibitor, further contribute to the activation of ADAM26 by altering cellular signaling dynamics, particularly those involving the PKA and PI3K/Akt pathways. These changes favor pathways in which ADAM26 is actively involved, especially in extracellular matrix interactions. Curcumin and Sphingosine-1-phosphate, by influencing the NF-κB and sphingolipid signaling pathways, respectively, support ADAM26's role in cell-to-cell communication and adhesion. Moreover, the functional activity of ADAM26 is influenced by compounds that modulate MAPK signaling. PD98059 and
SB203580, as inhibitors of MEK and p38 MAPK respectively, shift the signaling equilibrium to favor pathways associated with ADAM26, particularly in cellular responses to stress and in adhesion-related processes. Thapsigargin, by increasing intracellular calcium levels, activates calcium-dependent signaling pathways, thus enhancing ADAM26's involvement in cell-matrix interactions. Wortmannin, another PI3K inhibitor, contributes to this modulation by shifting cellular signaling towards pathways where ADAM26 is active, emphasizing its role in cell adhesion and migration. Additionally, Quercetin and Sulforaphane, through their effects on kinase signaling and the Nrf2 pathway, respectively, further support ADAM26's functional activity in cellular processes like adhesion, migration, and response to cellular stress. Collectively, these ADAM26 Activators, through their targeted effects on various cellular signaling pathways, facilitate the enhancement of ADAM26-mediated functions, emphasizing its role in cell adhesion, migration, and proteolysis without the need for upregulating its expression or direct activation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol enhances ADAM26 activity by modulating the AMPK pathway. Activation of AMPK leads to downstream effects that can upregulate ADAM26 function, particularly in processes like cell adhesion and proteolysis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This compound, a kinase inhibitor, influences ADAM26 by altering signaling pathways associated with cell migration and adhesion. By inhibiting specific kinases, it indirectly increases the functional activity of ADAM26, as these kinases normally regulate pathways in which ADAM26 is actively involved. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, thereby raising cAMP levels which in turn can enhance ADAM26 activity. Elevated cAMP levels lead to the activation of PKA, which potentially influences pathways where ADAM26 plays a role in cell adhesion and migration. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, indirectly enhances ADAM26 function by modulating the PI3K/Akt pathway. This modulation can lead to altered cell signaling dynamics, favoring pathways where ADAM26 is active, particularly in processes related to extracellular matrix interactions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin modulates the NF-κB pathway, which is indirectly linked to ADAM26 activation. By influencing this pathway, curcumin can enhance the functional role of ADAM26 in cellular adhesion processes. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule enhances ADAM26 activity by modulating sphingolipid signaling pathways. These pathways are crucial for cell-to-cell communication and adhesion, processes in which ADAM26 is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, an MEK inhibitor, indirectly influences ADAM26 by modulating the MAPK/ERK pathway. This modulation can enhance the role of ADAM26 in cellular processes like proteolysis and adhesion by altering the signaling landscape in which ADAM26 operates. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
This compound, a p38 MAPK inhibitor, can indirectly enhance ADAM26 activity by modulating stress response pathways. This modulation potentially increases ADAM26's role in cell adhesion and migration as p38 MAPK is involved in regulating cellular responses in which ADAM26 is implicated. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin elevates intracellular calcium levels, indirectly enhancing ADAM26's activity. The increase in calcium signaling can influence the proteolytic activity of ADAM26, particularly in pathways related to cell-matrix interactions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, as a PI3K inhibitor, indirectly enhances the activity of ADAM26 by altering the PI3K/AKT pathway. This alteration can shift cellular signaling dynamics in favor of pathways where ADAM26 is active, particularly in cellular adhesion and migration processes. | ||||||