ADA3 Inhibitors
ADA3 Inhibitors predominantly focus on modulating the histone acetyltransferase (HAT) activities, given ADA3's intrinsic role in these complexes and the subsequent impact on transcriptional regulation. Compounds like, Curcumin,, Epigallocatechin-3-gallate (EGCG), BML-210, MB-3, and C646 serve as either direct or indirect inhibitors of HAT, thereby potentially hindering ADA3's facilitative role in transcriptional activation. By modulating the HDAC activities, these chemicals can indirectly influence ADA3's role by shifting the overall balance of acetylation within the cell. This dynamic interplay between acetylation and deacetylation, facilitated by HAT and HDAC respectively, underscores the complex balance of chromatin remodeling where ADA3 operates.
Additionally, compounds like ICG-001, which target specific signaling pathways such as the Wnt pathway, provide an indirect approach to influence ADA3's downstream effects. By manipulating the upstream signaling, the subsequent transcriptional regulation mediated by ADA3 can be affected.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known to inhibit HAT activity, thereby influencing ADA3-mediated acetylation and transcriptional regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
An inhibitor of HAT which can modify ADA3's impact on chromatin dynamics. | ||||||
Butyrolactone 3 | 778649-18-6 | sc-358657 sc-358657A sc-358657B | 5 mg 50 mg 100 mg | $219.00 $1467.00 $2819.00 | 3 | |
HAT inhibitor that can suppress ADA3-mediated transcriptional regulation. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
Specific p300 HAT inhibitor which, by affecting p300, can influence ADA3-associated HAT activities. | ||||||