ACPL2 Activators
ACPL2 activators represent a class of chemical compounds that, through their influence on various signaling pathways, can indirectly enhance the functional activity of the ACPL2 protein. Compounds such as forskolin and IBMX work by elevating intracellular cAMP, thereby maintaining PKA activity which could enhance ACPL2 function if it is subject to regulation by phosphorylation. Similarly, ionophores like ionomycin and A23187 increase intracellular Ca2+ concentrations, activating calcium-dependent kinases that might phosphorylate ACPL2 or modulate its activity indirectly. The role of kinases in the regulation of ACPL2 can also be investigated using various kinase inhibitors such as genistein, LY294002, and PD98059. These compounds inhibit specific kinases,altering the signaling cascades that may control ACPL2 activity.
Other compounds like PMA and thapsigargin target PKC and SERCA, respectively, both of which can influence signaling pathways involving calcium ions and other second messengers that could indirectly affect ACPL2.Furthermore, natural compounds like epigallocatechin gallate (EGCG) have been shown to have a broad impact on protein kinases and could modify ACPL2 function if it is part of the affected pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP can enhance PKA activity, which may phosphorylate ACPL2 or related regulatory proteins, leading to enhanced ACPL2 function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents cAMP degradation. By maintaining cAMP levels, IBMX can indirectly sustain PKA activity that might enhance ACPL2 function by phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore for Ca2+. Increased intracellular calcium can activate calmodulin-dependent kinases, which may phosphorylate ACPL2 or associated proteins, resulting in enhanced ACPL2 activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can then phosphorylate and activate proteins within the same pathway as ACPL2, possibly resulting in its enhanced function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore, which raises intracellular calcium levels, potentially activating pathways that lead to ACPL2 activation through calcium-sensitive proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic Ca2+ levels and activation of calcium-dependent signaling, which could indirectly activate ACPL2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits various protein kinases and has been shown to modify signaling pathways; this modification could lead to the alteration of ACPL2 function if ACPL2 is part of these pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can modulate signaling pathways by preventing phosphorylation events. If ACPL2 activity is regulated by tyrosine phosphorylation, genistein might indirectly enhance the function of ACPL2 by modulating its regulatory kinases. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which can modulate the PI3K/Akt pathway. If ACPL2 activity is influenced by Akt-mediated signaling, this compound could indirectly enhance ACPL2's functional state through pathway modulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, indirectly affecting the MAPK/ERK pathway. If ACPL2 is regulated by this pathway, inhibition of upstream kinases could result in a compensatory enhancement of ACPL2 activity. | ||||||