Date published: 2025-9-29

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Acid Halides

Santa Cruz Biotechnology now offers a broad range of Acid Halides for use in various applications. Acid halides, also known as acyl halides, are a class of organic compounds derived from carboxylic acids by replacing the hydroxyl group (-OH) with a halide group (such as chloride, bromide, or fluoride). These compounds are highly reactive intermediates in organic synthesis due to the electrophilic nature of the carbonyl carbon, which readily undergoes nucleophilic acyl substitution reactions. Acid halides are pivotal in the synthesis of a wide array of chemical compounds, including esters, amides, and anhydrides, making them indispensable in chemical research and industrial processes. In scientific research, acid halides are frequently used to study reaction mechanisms and to develop new synthetic methodologies. Their reactivity also allows for the modification of complex molecules, facilitating the construction of elaborate molecular architectures and the introduction of functional groups that can be further manipulated. Additionally, acid halides play a crucial role in polymer chemistry, where they are used to produce polymers with specific structural and functional properties. Researchers have employed acid halides to explore the synthesis of novel materials, catalysts, and ligands, thereby advancing the fields of materials science, catalysis, and coordination chemistry. The availability of a wide variety of acid halides from Santa Cruz Biotechnology enables researchers to select the appropriate compound for their specific needs, thus driving innovation and discovery in multiple scientific disciplines. View detailed information on our available acid halides by clicking on the product name.

Items 11 to 20 of 374 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

4-Bromothiophene-3-carbonyl chloride

72899-51-5sc-261865
sc-261865A
250 mg
1 g
$129.00
$216.00
(0)

4-Bromothiophene-3-carbonyl chloride is a potent acid halide characterized by its unique thiophene ring structure, which imparts distinct electronic properties. The presence of the bromine atom enhances its electrophilicity, promoting rapid nucleophilic attack. This compound exhibits a high degree of reactivity, particularly in acylation reactions, where it can form stable intermediates. Its moderate boiling point and solubility in organic solvents facilitate efficient handling in synthetic processes, making it a versatile reagent in organic chemistry.

Acetyl chloride

75-36-5sc-207253
sc-207253A
25 g
500 g
$30.00
$50.00
(0)

Acetyl chloride is a highly reactive acid halide known for its ability to undergo nucleophilic acyl substitution reactions. Its carbonyl carbon is electrophilic, making it susceptible to attack by nucleophiles, leading to the formation of acyl derivatives. The presence of the chlorine atom enhances its reactivity, facilitating rapid esterification and acylation processes. Additionally, it can participate in Friedel-Crafts acylation, showcasing its versatility in organic synthesis.

Butyryl chloride

141-75-3sc-239451
250 g
$34.00
(0)

Butyryl chloride is a versatile acid halide known for its strong electrophilic nature, primarily due to the presence of a carbonyl group adjacent to a halogen. This configuration promotes rapid nucleophilic attack, leading to the formation of various acyl derivatives. It is a colorless liquid with a distinctive, sharp odor and a relatively low boiling point. The compound's reactivity is further modulated by its chain length, influencing reaction kinetics and selectivity in synthetic pathways.

Hexanoyl chloride

142-61-0sc-250109
sc-250109A
25 ml
100 ml
$45.00
$67.00
(0)

Hexanoyl chloride is a potent acid halide characterized by its strong electrophilic carbonyl group, which readily engages in nucleophilic attacks. The chlorine atom significantly increases its reactivity, allowing for swift acylation reactions. This compound can also promote the formation of anhydrides and esters through its interactions with alcohols and amines.

Nonafluoropentanoyl chloride

375-60-0sc-263959
5 g
$270.00
(0)

Nonafluoropentanoyl chloride is a highly reactive acid halide distinguished by its perfluorinated carbon chain, which imparts unique electronic properties. The presence of fluorine atoms enhances the electrophilicity of the carbonyl carbon, facilitating rapid acylation with nucleophiles. This compound exhibits remarkable stability against hydrolysis, allowing for controlled reactions in diverse environments. Its distinct molecular interactions enable the formation of complex derivatives, expanding its utility in synthetic chemistry.

5H-Octafluorovaleroyl chloride

376-71-6sc-262740
1 g
$74.00
(0)

5H-Octafluorovaleroyl chloride is an acid halide characterized by its unique fluorinated structure, which enhances its electrophilicity. This compound readily participates in acylation reactions, forming stable acyl derivatives with nucleophiles. Its strong electron-withdrawing fluorine atoms influence reaction kinetics, promoting rapid esterification and amidation processes.

2-Chlorobenzoyl chloride

609-65-4sc-237995
100 g
$29.00
(0)

2-Chlorobenzoyl chloride is a reactive acid halide known for its ability to engage in acylation reactions with various nucleophiles, leading to the formation of diverse acyl derivatives. The presence of the chlorine atom enhances its electrophilic nature, facilitating rapid reaction kinetics. This compound exhibits unique solubility properties due to its aromatic structure, influencing its interactions in organic synthesis and making it a key player in the development of complex molecular architectures.

Methyl 4-chloro-4-oxobutyrate

1490-25-1sc-250357
sc-250357A
5 g
25 g
$37.00
$106.00
(0)

Methyl 4-chloro-4-oxobutyrate is a versatile acid halide characterized by its electrophilic carbonyl group, which readily participates in nucleophilic acyl substitution reactions. The presence of the chloro substituent enhances its reactivity, allowing for efficient formation of esters and amides. Its unique steric and electronic properties facilitate selective reactions, making it an important intermediate in synthetic pathways. Additionally, its polar nature influences solubility and reactivity in various organic solvents.

Bromodifluoroacetyl bromide

1796-12-9sc-263057
sc-263057A
10 g
25 g
$497.00
$940.00
(0)

Bromodifluoroacetyl bromide is a reactive acid halide distinguished by its dual bromine substituents and electron-withdrawing fluorine atoms. This configuration enhances its electrophilicity, promoting rapid nucleophilic attack. The compound's unique steric hindrance and polar characteristics lead to selective reactivity in acylation reactions, facilitating the formation of diverse carbonyl derivatives. Its strong dipole moment also influences solvation dynamics, impacting reaction kinetics in various environments.

α-Chlorophenylacetyl chloride

2912-62-1sc-239154
10 g
$286.00
(0)

α-Chlorophenylacetyl chloride is a potent acid halide characterized by its chlorinated aromatic structure, which significantly enhances its electrophilic nature. The presence of the chlorine atom increases the compound's reactivity towards nucleophiles, facilitating acylation processes. Its unique steric profile allows for selective interactions with various nucleophiles, leading to distinct reaction pathways. Additionally, the compound's polar characteristics influence solubility and reactivity in diverse solvents, affecting overall reaction rates.