Abcg3 Activators
Chemical activators of ATP binding cassette subfamily G member 3 engage with various cellular pathways to modulate the activity of this protein. 4-Phenylbutyrate exerts its effects through histone deacetylase inhibition, which leads to enhanced acetylation of proteins, thus affecting their stability and function, resulting in increased activity of ATP binding cassette subfamily G member 3. Similarly, sulfasalazine works by inhibiting the factor NF-kB, which regulates the expression of certain transporters, including ATP binding cassette subfamily G member 3, leading to its activation by diminishing repression. GW4064, a synthetic FXR agonist, activates the farnesoid X receptor, which then upregulates the expression and activity of ATP binding cassette subfamily G member 3 via the FXR-mediated transcriptional pathway. T0901317, targeting the liver X receptor, and chenodeoxycholic acid, an endogenous FXR ligand, both facilitate the activation of ATP binding cassette subfamily G member 3 through similar receptor-dependent signaling pathways, enhancing the transcription of genes that are critical for lipid metabolism and transport.
Further, pregnenolone 16α-carbonitrile induces the pregnane X receptor, which subsequently increases the expression of genes involved in xenobiotic metabolism, leading to the activation of ATP binding cassette subfamily G member 3. Pioglitazone, by activating PPAR-gamma, and oleanolic acid, activating the PPAR signaling pathway, both contribute to the modulation of gene transcription encoding ABC transporters, thereby facilitating the activity of ATP binding cassette subfamily G member 3. Rifampicin, a potent inducer of PXR, and dexamethasone, through glucocorticoid receptor-mediated signaling, both promote the activation of ATP binding cassette subfamily G member 3 by influencing the expression and activity of various ABC transporters. Additionally, natural compounds like chrysin and curcumin engage with PPAR-mediated and NF-kB pathways, respectively, leading to the regulation of ATP binding cassette subfamily G member 3 activity and expression by modulating the transcription and activity of ABC transporters.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
4-Phenylbutyrate, a histone deacetylase inhibitor, can activate ATP binding cassette subfamily G member 3 by promoting acetylation that affects protein stability and function, leading to increased activity. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine is known to inhibit NF-kB, a factor that regulates the expression and activity of certain ABC transporters, thus its inhibition can lead to the activation of ATP binding cassette subfamily G member 3 by reducing its repression. | ||||||
GW 4064 | 278779-30-9 | sc-218577 | 5 mg | $95.00 | 13 | |
GW4064, a synthetic FXR agonist, activates the farnesoid X receptor which can increase the expression and activity of ATP binding cassette subfamily G member 3 through the FXR-mediated transcriptional pathway. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $89.00 $224.00 | 5 | |
T0901317 is a synthetic ligand for the liver X receptor which can enhance the activity of ATP binding cassette subfamily G member 3 through LXR-dependent upregulation of genes involved in lipid metabolism and transport. | ||||||
Chenodeoxycholic acid, free acid | 474-25-9 | sc-278835 sc-278835A | 1 g 5 g | $28.00 $117.00 | ||
Chenodeoxycholic acid (CDCA) is a natural bile acid that functions as an endogenous FXR ligand, which can activate ATP binding cassette subfamily G member 3 by promoting FXR-mediated transcriptional activation of genes involved in lipid transport. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a PPAR-gamma agonist, can activate ATP binding cassette subfamily G member 3 by binding to peroxisome proliferator-activated receptor-gamma, which may influence the transcription of genes encoding ABC transporters. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin acts as a potent inducer of PXR and can activate ATP binding cassette subfamily G member 3 by PXR-mediated signaling, which influences the expression and activity of various ABC transporters. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone can activate ATP binding cassette subfamily G member 3 through glucocorticoid receptor-mediated signaling, potentially affecting the expression and functional activity of ABC transporters. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid is known to activate the PPAR signaling pathway, which can lead to the activation of ATP binding cassette subfamily G member 3 by modulating the transcription of genes involved in lipid homeostasis. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin is a natural flavonoid that can activate ATP binding cassette subfamily G member 3 by influencing PPAR-mediated signaling pathways, which affect the transcription and activity of ABC transporters. | ||||||